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PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant (ab141406)

  • Datasheet
  • SDS
  • COA
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Chemical Structure - PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant (ab141406)

    Key features and details

    • Selective NF-κB inhibitor; antioxidant
    • CAS Number: 5108-96-3
    • Soluble in DMSO to 100 mM and in ethanol to 100 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant
    • Description

      Selective NF-κB inhibitor; antioxidant
    • Alternative names

      • Ammonium pyrrolidinedithiocarbamate
    • CAS Number

      5108-96-3
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      1-Pyrrolidinecarbodithioic acid ammonium salt
    • Molecular weight

      164.28
    • Molecular formula

      C5H9NS2.NH3
    • PubChem identifier

      517348
    • Storage instructions

      Store at +4°C. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 100 mM and in ethanol to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      C1CCN(C1)C(=S)[S-].[NH4+]
    • Source

      Synthetic

    • Research areas

      • Neuroscience
      • Neurology process
      • Neurodegenerative disease
      • Parkinson's disease
      • Other
      • Neuroscience
      • Cell Type Marker
      • Neuron marker
      • Soma marker
      • Immunology
      • Innate Immunity
      • Macrophage / Inflamm.
      • Signal Transduction
      • Signaling Pathway
      • Lipid Signaling
      • Prostaglandins
      • Neuroscience
      • Neurology process
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      • Nitric oxide & oxidative stress
      • Antioxidants
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      • Pharmacology
      • Signaling
      • Signal transduction
      • Cytokines, NF-κB & IκB signaling
      • Biochemicals
      • Research Area
      • Heart disease
      • Signaling
      • Nitric Oxide
      • Antioxidants
      • Biochemicals
      • Research Area
      • Heart disease
      • Signaling
      • Cytokine and NF-κB signaling
      • NF-κB & IκB
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • Signaling
      • Nitric Oxide
      • Antioxidants
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • Signaling
      • Cytokine and NF-κB signaling
      • NF-κB & IκB
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Nitric oxide signaling
      • Antioxidants
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Signaling
      • Signal transduction
      • Nitric oxide signaling
      • Antioxidants
      • Biochemicals
      • Research Area
      • Diabetes
      • Nitric oxide signaling
      • Antioxidants
      • Biochemicals
      • Research Area
      • Diabetes
      • Signaling
      • Signal transduction
      • Nitric oxide signaling
      • Antioxidants
      • Biochemicals
      • Research Area
      • Heart disease
      • Nitric oxide signaling
      • Antioxidants
      • Biochemicals
      • Research Area
      • Hypertension
      • Nitric oxide signaling
      • Antioxidants
      • Biochemicals
      • Research Area
      • Hypertension
      • Signaling
      • Signal transduction
      • Nitric oxide signaling
      • Antioxidants
      • Biochemicals
      • Research Area
      • Obesity
      • Nitric oxide signaling
      • Antioxidants
      • Biochemicals
      • Research Area
      • Obesity
      • Signaling
      • Signal transduction
      • Nitric oxide signaling
      • Antioxidants
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • Nitric oxide signaling
      • Antioxidants
      • Biochemicals
      • Research Area
      • Respiratory disease
      • Nitric oxide signaling
      • Antioxidants
      • Biochemicals
      • Research Area
      • Respiratory disease
      • Signaling
      • Nitric Oxide
      • Antioxidants
      • Biochemicals
      • Research Area
      • Respiratory disease
      • Signaling
      • Cytokine and NF-κB signaling
      • NF-κB & IκB
      • Biochemicals
      • Research Area
      • Stroke
      • Nitric oxide signaling
      • Antioxidants
      • Biochemicals
      • Research Area
      • Stroke
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      • Research Area
      • Cancer
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      • Nitric oxide & oxidative stress
      • Antioxidants
      • Biochemicals
      • Research Area
      • Cancer
      • Signal transduction
      • Cytokines, NF-κB & IκB signaling

    Images

    • Chemical Structure - PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant (ab141406)
      Chemical Structure - PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant (ab141406)
      2D chemical structure image of ab141406, PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (18)

    Publishing research using ab141406? Please let us know so that we can cite the reference in this datasheet.

    ab141406 has been referenced in 18 publications.

    • Nam JE  et al. Baicalin attenuates fibrogenic process in human renal proximal tubular cells (HK-2) exposed to diabetic milieu. Life Sci 254:117742 (2020). PubMed: 32360619
    • Zhang T  et al. Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner. Front Cell Dev Biol 8:784 (2020). PubMed: 32903542
    • Ding L  et al. CD10 expression identifies a subset of human perivascular progenitor cells with high proliferation and calcification potentials. Stem Cells 38:261-275 (2020). PubMed: 31721342
    • Tazawa K  et al. Transient Receptor Potential Ankyrin 1 Is Up-Regulated in Response to Lipopolysaccharide via P38/Mitogen-Activated Protein Kinase in Dental Pulp Cells and Promotes Mineralization. Am J Pathol 190:2417-2426 (2020). PubMed: 32919979
    • Song Y  et al. Separate administration of ammonium pyrrolidinedithiocarbamate and phorbol myristate acetate at early and late stages decreases secondary brain injury following intracerebral haemorrhage in rats via the NF-?B pathway. Folia Neuropathol 58:166-175 (2020). PubMed: 32729295
    View all Publications for this product

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