PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant (ab141406)
Key features and details
- Selective NF-κB inhibitor; antioxidant
- CAS Number: 5108-96-3
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant -
Description
Selective NF-κB inhibitor; antioxidant -
Alternative names
- Ammonium pyrrolidinedithiocarbamate
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CAS Number
5108-96-3 -
Chemical structure
Properties
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Chemical name
1-Pyrrolidinecarbodithioic acid ammonium salt -
Molecular weight
164.28 -
Molecular formula
C5H9NS2.NH3 -
PubChem identifier
517348 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CCN(C1)C(=S)[S-].[NH4+] -
Source
Synthetic
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Research areas
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- Antioxidants
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
Images
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Chemical Structure - PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant (ab141406)2D chemical structure image of ab141406, PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (18)
ab141406 has been referenced in 18 publications.
- Nam JE et al. Baicalin attenuates fibrogenic process in human renal proximal tubular cells (HK-2) exposed to diabetic milieu. Life Sci 254:117742 (2020). PubMed: 32360619
- Zhang T et al. Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner. Front Cell Dev Biol 8:784 (2020). PubMed: 32903542
- Ding L et al. CD10 expression identifies a subset of human perivascular progenitor cells with high proliferation and calcification potentials. Stem Cells 38:261-275 (2020). PubMed: 31721342
- Tazawa K et al. Transient Receptor Potential Ankyrin 1 Is Up-Regulated in Response to Lipopolysaccharide via P38/Mitogen-Activated Protein Kinase in Dental Pulp Cells and Promotes Mineralization. Am J Pathol 190:2417-2426 (2020). PubMed: 32919979
- Song Y et al. Separate administration of ammonium pyrrolidinedithiocarbamate and phorbol myristate acetate at early and late stages decreases secondary brain injury following intracerebral haemorrhage in rats via the NF-?B pathway. Folia Neuropathol 58:166-175 (2020). PubMed: 32729295