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    products/biochemicals/picrotoxin-gabaa-antagonist-ab120315.pdf

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Picrotoxin, GABAA antagonist (ab120315)

  • Datasheet
  • SDS
  • COA
Reviews (1) Submit a question References (62)

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Chemical Structure - Picrotoxin, GABA<sub>A</sub> antagonist (ab120315)

    Key features and details

    • GABAA antagonist
    • CAS Number: 124-87-8
    • Soluble in DMSO to 100 mM and in ethanol to 50 mM (with heating)
    • Form / State: Solid
    • Source: Anamirta cocculus

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    Overview

    • Product name

      Picrotoxin, GABAA antagonist
    • Description

      GABAA antagonist
    • Biological description

      Plant alkaloid. Non-competitive GABAA antagonist. Also inhibits homomeric glycine receptor. Convulsant in vivo.

    • General notes

      5g pack supplied as 5x1g

    • CAS Number

      124-87-8
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      1:1 mixture of picrotoxinin and picrotin
    • Molecular weight

      602.59
    • Molecular formula

      C30H34O13
    • PubChem identifier

      31304
    • Storage instructions

      Store at Room Temperature. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 100 mM and in ethanol to 50 mM (with heating)
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Toxic, refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CC(=C)[C@@H]1C2[C@@H]3[C@@]4([C@](C1C(=O)O2)(CC5[C@]4(O5)C(=O)O3)O)C.C[C@@]12[C@H]3C4[C@H](C([C@@]1(C[C@@H]5[C@]2(O5)C(=O)O3)O)C(=O)O4)C(C)(C)O
    • Source

      Anamirta cocculus

    • Research areas

      • Neuroscience
      • Neurotransmitter
      • Amino Acids
      • GABA
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • Ligand-Gated Ion Channels
      • Glycine Receptor
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Chemical Type
      • Toxin
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • GABA
      • GABAA
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Glycine
      • Antagonists
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • GABA
      • GABAA
      • Antagonists
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • GABA
      • GABAA
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • GABA
      • GABAA
      • Antagonists
      • Biochemicals
      • Research Area
      • Schizophrenia
      • GABA
      • GABAA
      • Biochemicals
      • Research Area
      • Schizophrenia
      • GABA
      • GABAA
      • Antagonists
      • Biochemicals
      • Research Area
      • Stress / Anxiety
      • GABA
      • GABAA
      • Biochemicals
      • Research Area
      • Stress / Anxiety
      • GABA
      • GABAA
      • Antagonists

    Images

    • Chemical Structure - Picrotoxin, GABA<sub>A</sub> antagonist (ab120315)
      Chemical Structure - Picrotoxin, GABAA antagonist (ab120315)
      2D chemical structure image of ab120315, Picrotoxin, GABAA antagonist

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (62)

    Publishing research using ab120315? Please let us know so that we can cite the reference in this datasheet.

    ab120315 has been referenced in 62 publications.

    • Wei XP  et al. A novel reticular node in the brainstem synchronizes neonatal mouse crying with breathing. Neuron 110:644-657.e6 (2022). PubMed: 34998469
    • Elmasri M  et al. Common synaptic phenotypes arising from diverse mutations in the human NMDA receptor subunit GluN2A. Commun Biol 5:174 (2022). PubMed: 35228668
    • Dingle YL  et al. Integrated functional neuronal network analysis of 3D silk-collagen scaffold-based mouse cortical culture. STAR Protoc 2:100292 (2021). PubMed: 33537680
    • Vierock J  et al. BiPOLES is an optogenetic tool developed for bidirectional dual-color control of neurons. Nat Commun 12:4527 (2021). PubMed: 34312384
    • Zhou Q  et al. Celsr3 is required for Purkinje cell maturation and regulates cerebellar postsynaptic plasticity. iScience 24:102812 (2021). PubMed: 34308297
    View all Publications for this product

    Customer reviews and Q&As

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    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

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    Verified customer

    Submitted Apr 01 2016

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