Q-DEVD-OPh, caspase-3 inhibitor (ab142037)
Key features and details
- Potent, irreversible, cell-permeable caspase-3 inhibitor
- CAS Number:
- Purity: > 90%
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Q-DEVD-OPh, caspase-3 inhibitor -
Description
Potent, irreversible, cell-permeable caspase-3 inhibitor -
Biological description
Potent, irreversible, cell-permeable caspase-3 inhibitor -
Purity
> 90% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called 1175 Caspase-3 Inhibitor Q-DEVD-OPh. 1175-5 is the same size as the 5 mg size of ab142037.
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Chemical structure
Properties
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Molecular weight
799.77 -
Molecular formula
C38H43F2N5O12 -
Sequence
DEVD (Modifications: N-terminal quinolyl; C-terminal OPh; Asp-1 = Asp(OMe); Glu-2 = Glu(OMe); Asp-4 = Asp(OMe)) -
PubChem identifier
44135278 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)C(C(=O)NC(CC(=O)OC)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C(CCC(=O)OC)NC(=O)C(CC(=O)OC)NC(=O)C2=NC3=CC=CC=C3C=C2 -
Source
Synthetic
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Research areas
Associated products
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Related Products
Images
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2D chemical structure image of ab142037, Q-DEVD-OPh, caspase-3 inhibitor
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Titration of the Caspase 3 specific inhibitor Q-DEVD-OPh (ab142037) (duplicates; +/- SD).
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab142037 has been referenced in 1 publication.
- Zhou XY et al. Inhibition of autophagy blocks cathepsins-tBid-mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytes. Cell Death Dis 8:e2618 (2017). PubMed: 28206988