QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker (ab120117)
Key features and details
- Na+ channel blocker
- CAS Number: 21306-56-9
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameQX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker
DescriptionNa+ channel blocker
- N-Ethyllidocaine bromide
A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ conductance when applied intracellularly.
Also available in simple stock solutions (ab144492) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical nameN-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120117 has been referenced in 13 publications.
- Tønnesen J et al. Super-Resolution Imaging of the Extracellular Space in Living Brain Tissue. Cell 172:1108-1121.e15 (2018). PubMed: 29474910
- Chu HY et al. Loss of Hyperdirect Pathway Cortico-Subthalamic Inputs Following Degeneration of Midbrain Dopamine Neurons. Neuron 95:1306-1318.e5 (2017). PubMed: 28910619
- Hsu TT et al. Differential Recruitment of Dentate Gyrus Interneuron Types by Commissural Versus Perforant Pathways. Cereb Cortex 26:2715-27 (2016). PubMed: 26045570
- Zonouzi M et al. GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury. Nat Neurosci 18:674-82 (2015). PubMed: 25821912
- Soiza-Reilly M et al. Presynaptic gating of excitation in the dorsal raphe nucleus by GABA. Proc Natl Acad Sci U S A 110:15800-5 (2013). PubMed: 24019494