(R)-Baclofen, GABAB agonist (ab120325)
Key features and details
- Selective GABAB agonist. Active enantiomer.
- CAS Number: 69308-37-8
- Soluble in water to 25 mM and in 1 eq. NaOH to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
(R)-Baclofen, GABAB agonist -
Description
Selective GABAB agonist. Active enantiomer. -
Biological description
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CAS Number
69308-37-8 -
Chemical structure
Properties
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Chemical name
(R)-4-Amino-3-(4-chlorophenyl)butanoic acid -
Molecular weight
213.66 -
Molecular formula
C10H12ClNO2 -
PubChem identifier
44602 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 25 mM and in 1 eq. NaOH to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Clc1ccc(cc1)[C@H](CN)CC(=O)O -
Source
Synthetic
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Research areas
Associated products
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Related Products
Images
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Chemical Structure - (R)-Baclofen, GABAB agonist (ab120325)2D chemical structure image of ab120325, (R)-Baclofen, GABAB agonist
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (4)
ab120325 has been referenced in 4 publications.
- Booker SA et al. Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network. Elife 9:N/A (2020). PubMed: 32073397
- Llamosas N et al. Inactivation of GIRK channels weakens the pre- and postsynaptic inhibitory activity in dorsal raphe neurons. Physiol Rep 5:N/A (2017). PubMed: 28196855
- Beckley JT et al. Medial prefrontal cortex inversely regulates toluene-induced changes in markers of synaptic plasticity of mesolimbic dopamine neurons. J Neurosci 33:804-13 (2013). PubMed: 23303956
- Wang X et al. Effects of the allosteric antagonist 1-(4-chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 receptor modulation in the cerebellum. Mol Pharmacol 79:758-67 (2011). PubMed: 21189269