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    products/biochemicals/resveratrol-antioxidant-polyphenol-ab120726.pdf

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Biochemicals Chemical Type Biochemicals
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Resveratrol, Antioxidant polyphenol (ab120726)

  • Datasheet
  • SDS
  • COA
Submit a review Submit a question References (6)

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Chemical Structure - Resveratrol, Antioxidant polyphenol (ab120726)
  • Immunocytochemistry/ Immunofluorescence - Resveratrol, Antioxidant polyphenol (ab120726)

Key features and details

  • Antioxidant polyphenol with a multitude of biological activities
  • CAS Number: 501-36-0
  • Purity: > 99%
  • Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    Resveratrol, Antioxidant polyphenol
  • Description

    Antioxidant polyphenol with a multitude of biological activities
  • Biological description

    Polyphenol found in grape skins and red wine. Displays a multitude of biological activities including antioxidant, antiplatelet, antitumor, anti-inflammatory and cardioprotective effects. Additionally, shows antiamyloidogenic and fibril-destabilizing activities.

  • Purity

    > 99%
  • CAS Number

    501-36-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3,benzenediol
  • Molecular weight

    228.25
  • Molecular formula

    C14H12O3
  • PubChem identifier

    445154
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Refer to SDS for further information

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O
  • Source

    Synthetic

  • Research areas

    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Signaling
    • Amyloidogenesis
    • Biochemicals
    • Pharmacology
    • Signaling
    • Signal transduction
    • Nitric oxide & oxidative stress
    • Antioxidants
    • Biochemicals
    • Research Area
    • Heart disease
    • Signaling
    • Amyloidogenesis
    • Biochemicals
    • Research Area
    • Heart disease
    • Signaling
    • Nitric Oxide
    • Antioxidants
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Signaling
    • Amyloidogenesis
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Signaling
    • Nitric Oxide
    • Antioxidants
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Nitric oxide signaling
    • Antioxidants
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Signaling
    • Amyloidogenesis
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Signaling
    • Signal transduction
    • Nitric oxide signaling
    • Antioxidants
    • Biochemicals
    • Research Area
    • Diabetes
    • Nitric oxide signaling
    • Antioxidants
    • Biochemicals
    • Research Area
    • Diabetes
    • Signaling
    • Amyloidogenesis
    • Biochemicals
    • Research Area
    • Diabetes
    • Signaling
    • Signal transduction
    • Nitric oxide signaling
    • Antioxidants
    • Biochemicals
    • Research Area
    • Heart disease
    • Nitric oxide signaling
    • Antioxidants
    • Biochemicals
    • Research Area
    • Hypertension
    • Nitric oxide signaling
    • Antioxidants
    • Biochemicals
    • Research Area
    • Hypertension
    • Signaling
    • Amyloidogenesis
    • Biochemicals
    • Research Area
    • Hypertension
    • Signaling
    • Signal transduction
    • Nitric oxide signaling
    • Antioxidants
    • Biochemicals
    • Research Area
    • Obesity
    • Nitric oxide signaling
    • Antioxidants
    • Biochemicals
    • Research Area
    • Obesity
    • Signaling
    • Amyloidogenesis
    • Biochemicals
    • Research Area
    • Obesity
    • Signaling
    • Signal transduction
    • Nitric oxide signaling
    • Antioxidants
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Nitric oxide signaling
    • Antioxidants
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Nitric oxide signaling
    • Antioxidants
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Signaling
    • Amyloidogenesis
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Signaling
    • Nitric Oxide
    • Antioxidants
    • Biochemicals
    • Research Area
    • Stroke
    • Nitric oxide signaling
    • Antioxidants
    • Biochemicals
    • Research Area
    • Stroke
    • Signaling
    • Amyloidogenesis
    • Biochemicals
    • Research Area
    • Stroke
    • Signaling
    • Signal transduction
    • Nitric oxide signaling
    • Antioxidants
    • Biochemicals
    • Research Area
    • Cancer
    • Signal transduction
    • Nitric oxide & oxidative stress
    • Antioxidants
    • Biochemicals
    • Pharmacology
    • Signaling
    • Immunomodulators
    • Immunomodulators & Immunosuppressants

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab120726 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.
Notes
Functional Studies
Use at an assay dependent concentration.

Images

  • Chemical Structure - Resveratrol, Antioxidant polyphenol (ab120726)
    Chemical Structure - Resveratrol, Antioxidant polyphenol (ab120726)
    2D chemical structure image of ab120726, Resveratrol, Antioxidant polyphenol
  • Immunocytochemistry/ Immunofluorescence - Resveratrol, Antioxidant polyphenol (ab120726)
    Immunocytochemistry/ Immunofluorescence - Resveratrol, Antioxidant polyphenol (ab120726)
    ab85555 staining PKM2 in HeLa cells treated with resveratrol (ab120726), by ICC/IF. Decrease in PKM2 expression correlates with increased concentration of resveratrol as described in literature.
    The cells were incubated at 37°C for 48h in media containing different concentrations of ab120726 (resveratrol) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab85555 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (6)

Publishing research using ab120726? Please let us know so that we can cite the reference in this datasheet.

ab120726 has been referenced in 6 publications.

  • Afewerky HK  et al. Sodium-calcium exchanger isoform-3 targeted Withania somnifera (L.) Dunal therapeutic intervention ameliorates cognition in the 5xFAD mouse model of Alzheimer's disease. Sci Rep 12:1537 (2022). PubMed: 35087161
  • Nevoral J  et al. Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis progression. J Anim Sci Biotechnol 10:67 (2019). PubMed: 31413827
  • Guo D  et al. Resveratrol protects early brain injury after subarachnoid hemorrhage by activating autophagy and inhibiting apoptosis mediated by the Akt/mTOR pathway. Neuroreport 29:368-379 (2018). PubMed: 29360689
  • Yao ZQ  et al. A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma. Cell Death Dis 9:767 (2018). PubMed: 29991742
  • Campo VA Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression. Int J Parasitol Drugs Drug Resist 7:23-33 (2017). PubMed: 28038431
  • Adamkova K  et al. SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development. J Anim Sci Biotechnol 8:83 (2017). PubMed: 29118980

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