Risperidone, 5-HT2A / D2 antagonist (ab120393)
Key features and details
- Atypical antipsychotic. 5-HT2A / D2 antagonist.
- CAS Number: 106266-06-2
- Soluble in DMSO to 10 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Risperidone, 5-HT2A / D2 antagonist -
Description
Atypical antipsychotic. 5-HT2A / D2 antagonist. -
Biological description
Atypical antipsychotic agent. Potent 5-HT2A antagonist (Ki = 0.4 nM). Also displays high affinity at D2 receptors (Ki = 3.13 nM).
-
CAS Number
106266-06-2 -
Chemical structure
Properties
-
Chemical name
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl] ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one -
Molecular weight
410.48 -
Molecular formula
C23H27FN4O2 -
PubChem identifier
5073 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM and in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC=5N=C1CCCCN1C(=O)C=5CCN2CCC(CC2)c4noc3cc(F)ccc34 -
Source
Synthetic
-
Research areas
Images
-
Chemical Structure - Risperidone, 5-HT2A / D2 antagonist (ab120393)2D chemical structure image of ab120393, Risperidone, 5-HT2A / D2 antagonist
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (3)
ab120393 has been referenced in 3 publications.
- Malekizadeh Y et al. Whole transcriptome in silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side effects. Alzheimers Dement (N Y) 6:e12078 (2020). PubMed: 32864416
- Blessing WW et al. Clozapine, chlorpromazine and risperidone dose-dependently reduce emotional hyperthermia, a biological marker of salience. Psychopharmacology (Berl) 234:3259-3269 (2017). PubMed: 28812124
- Fijal K et al. Co-administration of 5-HT6 receptor antagonists with clozapine, risperidone, and a 5-HT2A receptor antagonist: effects on prepulse inhibition in rats. Psychopharmacology (Berl) 231:269-81 (2014). Rat . PubMed: 23954911