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    products/biochemicals/rosiglitazone-maleate-avandia-ppargamma-agonist-maleate-salt-ab142461.pdf

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Rosiglitazone maleate (Avandia), PPARgamma agonist. Maleate salt. (ab142461)

  • Datasheet
  • SDS
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Chemical Structure - Rosiglitazone maleate (Avandia), PPARgamma agonist. Maleate salt. (ab142461)

    Key features and details

    • Potent, selective PPARγ agonist. Maleate salt.
    • CAS Number: 155141-29-0
    • Purity: > 98%
    • Soluble in DMSO and ethanol
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      Rosiglitazone maleate (Avandia), PPARgamma agonist. Maleate salt.
    • Description

      Potent, selective PPARγ agonist. Maleate salt.
    • Purity

      > 98%
    • CAS Number

      155141-29-0
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      5-[[4-[2-[Methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione maleate
    • Molecular weight

      473.51
    • Molecular formula

      C18H19N3O3S.C4H4O4
    • PubChem identifier

      5281055
    • Storage instructions

      Store at Room Temperature. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO and ethanol
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Toxic, refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3.C(=CC(=O)O)C(=O)O
    • Source

      Synthetic

    • Research areas

      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • Potassium Channels
      • Immunology
      • Innate Immunity
      • Macrophage / Inflamm.
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Domain Families
      • Zinc Finger
      • Signal Transduction
      • Metabolism
      • Plasma Membrane
      • Channels
      • Stem Cells
      • Mesenchymal Stem Cells
      • Adipogenesis
      • Cardiovascular
      • Blood
      • Blood Pressure regulation
      • Cardiovascular
      • Vasculature
      • Vasoconstriction
      • Other
      • Cardiovascular
      • Vasculature
      • Vasodilation
      • Other
      • Cancer
      • Cancer Metabolism
      • Response to hypoxia
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Nuclear Receptors
      • PPAR
      • Metabolism
      • Pathways and Processes
      • Metabolism processes
      • Hypoxia
      • Metabolism
      • Types of disease
      • Obesity

    Images

    • Chemical Structure - Rosiglitazone maleate (Avandia), PPARgamma agonist. Maleate salt. (ab142461)
      Chemical Structure - Rosiglitazone maleate (Avandia), PPARgamma agonist. Maleate salt. (ab142461)
      2D chemical structure image of ab142461, Rosiglitazone maleate (Avandia), PPARgamma agonist. Maleate salt.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (4)

    Publishing research using ab142461? Please let us know so that we can cite the reference in this datasheet.

    ab142461 has been referenced in 4 publications.

    • Aaron N  et al. Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells. Elife 10:N/A (2021). PubMed: 34155972
    • Liu L  et al. PPAR? Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment. Diabetes 69:1793-1803 (2020). PubMed: 32409492
    • Chan M  et al. Identification of a natural beige adipose depot in mice. J Biol Chem 294:6751-6761 (2019). PubMed: 30824545
    • Kraakman MJ  et al. PPAR? deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects. J Clin Invest 128:2600-2612 (2018). PubMed: 29589839

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