Ruthenium red, Ca2+ signaling inhibitor (ab120264)
Key features and details
- Ca2+ signaling inhibitor
- CAS Number: 11103-72-3
- Soluble in water to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ruthenium red, Ca2+ signaling inhibitor -
Description
Ca2+ signaling inhibitor -
Biological description
Ca2+ signaling inhibitor. Inhibits mitochondrial Ca2+ uniporter, Ca2+-ATPase, troponin C and calmodulin. Blocks intracellular Ca2+ release by ryanodine receptor from internal stores. Attenuates capsaicin-induced cation channel opening. Inhibits Ca2+-induced Ca2+ release from ryanodine-sensitive intracellular Ca2+ stores. Blocks large-conductance Ca2+-activated potassium channels
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CAS Number
11103-72-3 -
Chemical structure
Properties
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Chemical name
Ammoniated ruthenium oxychloride -
Molecular weight
786.35 -
Molecular formula
H42N14O2Ru3Cl6 -
PubChem identifier
16218584 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
N.N.N.N.N.N.N.N.N.N.N.N.N.N.O.O.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru+2].[Ru+2].[Ru+2] -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Ruthenium red, Ca2+ signaling inhibitor (ab120264)2D chemical structure image of ab120264, Ruthenium red, Ca2+ signaling inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (6)
ab120264 has been referenced in 6 publications.
- Song J et al. Inhibitory Effects of 6,8-Diprenylorobol on Endometriosis Progression in Humans by Disrupting Calcium Homeostasis and Mitochondrial Function. Antioxidants (Basel) 11:N/A (2022). PubMed: 35052675
- Park H et al. Ivermectin-induced programmed cell death and disruption of mitochondrial membrane potential in bovine mammary gland epithelial cells. Pestic Biochem Physiol 163:84-93 (2020). PubMed: 31973874
- Lu L et al. Dextran as an elicitor of phenylpropanoid and flavonoid biosynthesis in tomato fruit against gray mold infection. Carbohydr Polym 225:115236 (2019). PubMed: 31521274
- Weber L et al. Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis. PLoS One 12:e0172491 (2017). PubMed: 28273117
- Arduino DM et al. Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening. Mol Cell 67:711-723.e7 (2017). PubMed: 28820965
- Ryskamp DA et al. The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells. J Neurosci 31:7089-101 (2011). PubMed: 21562271