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(S)-3,4-DCPG (UBP1109), mGlu8a agonist (ab120006)

Submit a review Q&A (4)References (3)
Chemical Structure - (S)-3,4-DCPG (UBP1109), mGlu<sub>8a</sub> agonist (ab120006)

    Key features and details

    • mGlu8a agonist
    • CAS Number: 201730-11-2
    • Soluble in water to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      (S)-3,4-DCPG (UBP1109), mGlu8a agonist

    • Description

      mGlu8a agonist

    • Alternative names

      • UBP1109

    • Biological description

      Potent, selective mGlu8a agonist (EC50 = 31 nM). Displays >100-fold selectivity over mGlu1-7. Systemically active in vivo.

      Also available in simple stock solutions (ab146696) - add 1 ml of water to get an exact, ready-to-use concentration.

    • CAS Number

      201730-11-2

    • Chemical structure

      Chemical Structure

    Properties

    Images

    • Chemical Structure - (S)-3,4-DCPG (UBP1109), mGlu<sub>8a</sub> agonist (ab120006)
      Chemical Structure - (S)-3,4-DCPG (UBP1109), mGlu8a agonist (ab120006)
      2D chemical structure image of ab120006, (S)-3,4-DCPG (UBP1109), mGlu8a agonist

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (3)

    Publishing research using ab120006? Please let us know so that we can cite the reference in this datasheet.

    ab120006 has been referenced in 3 publications.

    • Gosnell HB  et al. mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner. Neuropsychopharmacology 36:1599-607 (2011). PubMed: 21451497
    • Beurrier C  et al. Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism. FASEB J 23:3619-28 (2009). PubMed: 19525404
    • Lopez S  et al. Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease. J Neurosci 27:6701-11 (2007). PubMed: 17581957

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    1-4 of 4 Abreviews or Q&A

    Question

    Dear xxxx,

    Thank you for dealing with this so quickly and for sending a replacement, I appreciate your help.

    Kind regards,

    Read More
    Answer

    That is no problem. If you have any further problems please do not hesitate to contact us again.



    I wish you all the best with your research.

    Read More

    Question

    The lot number on the vial is APN05015-1-4, and that on the documentation is APN08161-9-7. Is there anyway of being sure which is the right one, or will I need to get a new batch sent? Thank you for letting me know as soon as possible.

    Kind regards,

    Read More
    Answer

    Thank you for providing that information.

    I have had a talk with our department that handles the processing of stock and sending it out. It seems that unfortunately you were sent the incorrect documentation for the lot number of the product. Therefore the molecular weight of the product should match to that stated on the vial of the product. However, as I am not 100% sure that it was not a labeling error (and the product you have is from a different vial) I have arranged for a replacement to be sent out to you.

    I am sorry thatthis error has occurred.It appears thatit may be as a result of us starting to handle the products of Ascent andthe logistics that this has involved.I am certain that the vial that you are now being sent willbe correct. The order number of thenew vial is1065737(Purchaseorder numberFOCR FMVS1142495).As we are coming into Easter itis likely that this will not reach you until next week.

    I am sorryfor any inconvenience this problem has caused you.If you have any problems receiving the replacementproduct please do let me know.

    Read More

    Question

    Customer reposting discrepency between the Mw stated on the vial (261.7) and that stated for the batch (252.7).

    Read More
    Answer

    Sorry for the delay in getting back to you.

    I have checked some lots of (S)-3,4-DCPG (UBP1109) that we have in stock and it seems that the certificate of analysis documentation and the molecular weight presented on the vial itself match. I am unsure as to why yours are different.

    Could you please check the lot number on the certificate of analysis provided to you, as well as that on the vial you received and let me knowwhat they are? This number should start with APN.

    I will try to resolve this situation as quickly as I can. I am sorry for any inconvenience this problem is causing you.

    Read More

    Question

    Hello,

    I have been purchasing (S)-3,4-Dicarboxyphenyglycine from you over the
    past year, and would like to enquire whether there are any known
    impurities in this compound, and if so what is the identity and % of
    these impurites. The latest batch ordered was batch no. APN10024-4-4.
    Thank you for any help you may be able to provide on this matter.
    Kind regards,

    Read More
    Answer

    Thank you for your reply and for kindly providing the product code.

    The purity of this compound ((S)-3,4-DCPG) is checked by several analytical techniques including chiral HPLC and contains less than 1% of any other compound. The only identified impurity is the other isomer (R)-3,4-DCPG which varies between batches but is at a level of 0.8% in batch APN10024-4-4.

    I hope this information will be helpful to you. if you have any further questions, or if you have some concerns regarding the results from this product, please do not hesitate to contact me.

    Read More

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