S-Methyl-N,N-diethylthiocarbamate Sulfone (MeDTC), aldehyde dehydrogenase inhibitor (ab144779)
Key features and details
- Potent irreversible inhibitor of low Km mitochondrial aldehyde dehydrogenase (ALDH)
- CAS Number: 155514-79-7
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
S-Methyl-N,N-diethylthiocarbamate Sulfone (MeDTC), aldehyde dehydrogenase inhibitor -
Description
Potent irreversible inhibitor of low Km mitochondrial aldehyde dehydrogenase (ALDH) -
Alternative names
- MeDTC
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Biological description
Potent irreversible inhibitor of low Km mitochondrial aldehyde dehydrogenase (ALDH) (IC50 = 420 nM). Dioxygenated metabolite of disulfiram. Potential use in embryogenic studies and retinoic acid signaling. Active in vitro and in vivo. -
CAS Number
155514-79-7 -
Chemical structure
Properties
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Chemical name
N,N-Diethyl-1-methylsulfonylformamide -
Molecular weight
179.24 -
Molecular formula
C6H13NO3S -
PubChem identifier
3552889 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCN(CC)C(=O)S(=O)(=O)C -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab144779 has not yet been referenced specifically in any publications.