SB 203580, p38 MAPK inhibitor (ab120162)
Key features and details
- p38 MAPK inhibitor
- CAS Number: 152121-47-6
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SB 203580, p38 MAPK inhibitor -
Description
p38 MAPK inhibitor -
Biological description
Cell-permeable p38 MAPK inhibitor. Shows selectivity over many other kinases but also shown to have some inhibitory activity against GAK, CK1, RIP2, c-Raf and GSK3.
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CAS Number
152121-47-6 -
Chemical structure
Properties
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Chemical name
4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine -
Molecular weight
377.43 -
Molecular formula
C21H16FN3OS -
PubChem identifier
176155 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CS(=O)c1ccc(cc1)c2nc(c(n2)c3ccncc3)c4ccc(F)cc4 -
Source
Synthetic
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Research areas
Images
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Chemical Structure - SB 203580, p38 MAPK inhibitor (ab120162)2D chemical structure image of ab120162, SB 203580, p38 MAPK inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (24)
ab120162 has been referenced in 24 publications.
- Zhang J et al. TGF-ß1-induced autophagy activates hepatic stellate cells via the ERK and JNK signaling pathways. Int J Mol Med 47:256-266 (2021). PubMed: 33236148
- Li HN et al. Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-a through activating ERK, p38 MAPK, and JAK2/STAT3. J Neuroinflammation 18:150 (2021). PubMed: 34225736
- Lan CN et al. MAPK inhibitors protect against early-stage osteoarthritis by activating autophagy. Mol Med Rep 24:N/A (2021). PubMed: 34590154
- Zhang X et al. MicroRNA-375 prevents TGF-ß-dependent transdifferentiation of lung fibroblasts via the MAP2K6/P38 pathway. Mol Med Rep 22:1803-1810 (2020). PubMed: 32582987
- Kang K & Wang Y Sevoflurane Inhibits Proliferation and Invasion of Human Ovarian Cancer Cells by Regulating JNK and p38 MAPK Signaling Pathway. Drug Des Devel Ther 13:4451-4460 (2019). PubMed: 32021086