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    products/biochemicals/sb431542-alk-inhibitor-ab120163.pdf

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Cardiovascular Angiogenesis Growth Factors TGF
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SB431542, ALK inhibitor (ab120163)

  • Datasheet
  • COA
Submit a review Q&A (2)References (25)

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Chemical Structure - SB431542, ALK inhibitor (ab120163)

    Key features and details

    • ALK inhibitor
    • CAS Number: 301836-41-9
    • Soluble in DMSO to 100 mM and in ethanol to 10 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      SB431542, ALK inhibitor
    • Description

      ALK inhibitor
    • Biological description

      Potent and selective inhibitor of Activin Like Kinase. Inhibits ALK 4, 5 (IC50 = 94 nM), and 7. 3D Growth matrix component; also component of brain and blood vessel organoid differentiation media.

    • CAS Number

      301836-41-9
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide
    • Molecular weight

      384.39
    • Molecular formula

      C22H16N4O3
    • PubChem identifier

      4521392
    • Storage instructions

      Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 100 mM and in ethanol to 10 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      NC(=O)c1ccc(cc1)c3nc(c2ccccn2)c(n3)c4ccc5OCOc5c4
    • Source

      Synthetic

    • Research areas

      • Cardiovascular
      • Angiogenesis
      • Growth Factors
      • TGF
      • Signal Transduction
      • Cytoskeleton / ECM
      • Cytoskeleton
      • Microfilaments
      • Actin etc
      • Actin Binding Proteins
      • Signal Transduction
      • Protein Phosphorylation
      • Ser / Thr Kinases
      • PKB / AKT
      • Signal Transduction
      • Protein Phosphorylation
      • Ser / Thr Kinases
      • Other Kinases
      • Signal Transduction
      • Growth Factors/Hormones
      • TGF
      • Signal Transduction
      • Signaling Pathway
      • Nuclear Signaling
      • SMADs
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • SMADs
      • Stem Cells
      • Signaling Pathways
      • TGF beta
      • Surface Molecules
      • Cancer
      • Growth factors
      • TGF
      • Cancer
      • Oncoproteins/suppressors
      • Oncoproteins
      • Growth factor receptors
      • Cancer
      • Cancer Metabolism
      • Response to hypoxia
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Metabolism
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      • Metabolism processes
      • Hypoxia
      • Biochemicals
      • Pharmacology
      • Signaling
      • Stem Cells
      • Other
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Enzyme-Linked Receptors
      • Receptor Serine/Threonine Kinases (RSTKs)

    Images

    • Chemical Structure - SB431542, ALK inhibitor (ab120163)
      Chemical Structure - SB431542, ALK inhibitor (ab120163)
      2D chemical structure image of ab120163, SB431542, ALK inhibitor

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download
    • COA

    References (25)

    Publishing research using ab120163? Please let us know so that we can cite the reference in this datasheet.

    ab120163 has been referenced in 25 publications.

    • Zhang M  et al. Prkg2 regulates alveolar type 2-mediated re-alveolarization. Stem Cell Res Ther 13:111 (2022). PubMed: 35313961
    • Keatinge M  et al. CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. PLoS Genet 17:e1009515 (2021). PubMed: 33914736
    • Liberti DC  et al. Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury. Cell Rep 35:109092 (2021). PubMed: 33979629
    • Katsura H  et al. Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction. Cell Stem Cell 27:890-904.e8 (2020). PubMed: 33128895
    • Xiang Y  et al. Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development. STAR Protoc 1:N/A (2020). PubMed: 33103124
    View all Publications for this product

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    1-2 of 2 Abreviews or Q&A

    Question

    1. What is the molecular weight?
    2. Does the molecular weight include just the compound or is it the compound + water?
    3. Is water still part of the molecule even after dessication?

    Read More

    Abcam community

    Verified customer

    Asked on Nov 14 2012

    Answer


    Q1. What is the molecular weight of SB431542?
    A1. The molecular weight of this molecule as measured by mass spec (as can be found under the Analysis section of the COA) is 385.2 daltons. The molecular weight to use for calculations by the user is the Batch molecular weight. The batch molecular weight takes into account any additional water molecules or other ions that are part of the compound from this batch.
    Q2. Does the molecular weight include just the compound or is it the compound + water?
    A2. The batch molecular weight includes the compound plus any water molecules that get incorporated into the molecule.
    Q3. Is water still part of the molecule even after dessication?
    Q3. Yes, the 2 water molecules (noted on the batch molecular formula as ".2 H20" remain as part of the compound even after dessication.

    Read More

    Abcam Scientific Support

    Answered on Nov 14 2012

    Question

    I purchased ab120163. The molecular weight noted on the online product datasheet is 384.39 however the molecular weight printed on the packaging and label is 420.42. What is the reason for this difference?

    Read More

    Abcam community

    Verified customer

    Asked on Oct 26 2012

    Answer

    Information about the molecular weights can be found on the Biochemicals FAQ page.
    'Molecular weight and molecular formula
    The molecular weight and formula published on our website represent the molecular weight and formula of the product as depicted in the chemical structure displayed on our website. However, molecular weights (and formulae) can vary slightly from batch to batch - due to water composition, or due to a change of salt. These changes will be indicated on the Certificate of authenticity that accompanies your product. The changes should not affect the biological activity of your product, but it is important that you take them into account when making up solutions. You should therefore always use the batch molecular weight as stated on the Certificate of authenticity or the vial label.'

    Read More

    Abcam Scientific Support

    Answered on Oct 26 2012

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
    For licensing inquiries, please contact partnerships@abcam.com

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