SCH 23390 hydrochloride, D1-like dopamine receptor antagonist (ab120597)
Key features and details
- Selective D1-like dopamine receptor antagonist
- CAS Number: 125941-87-9
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SCH 23390 hydrochloride, D1-like dopamine receptor antagonist -
Description
Selective D1-like dopamine receptor antagonist -
Purity
> 99% -
CAS Number
125941-87-9 -
Chemical structure
Properties
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Chemical name
(R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride -
Molecular weight
324.25 -
Molecular formula
C17H18ClNO.HCl -
PubChem identifier
11957535 -
Storage instructions
Store at +4°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CCC2=CC(=C(C=C2[C@H](C1)C3=CC=CC=C3)O)Cl.Cl -
Source
Synthetic
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Research areas
Images
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Chemical Structure - SCH 23390 hydrochloride, D1-like dopamine receptor antagonist (ab120597)2D chemical structure image of ab120597, SCH 23390 hydrochloride, D1-like dopamine receptor antagonist
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (5)
ab120597 has been referenced in 5 publications.
- Burke DA & Alvarez VA Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens. Cell Rep 39:110795 (2022). PubMed: 35545050
- Wang L et al. A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging. Nat Commun 13:5363 (2022). PubMed: 36097007
- Bocarsly ME et al. A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors. Cell Rep 29:1147-1163.e5 (2019). PubMed: 31665630
- Spigolon G et al. cJun N-terminal kinase (JNK) mediates cortico-striatal signaling in a model of Parkinson's disease. Neurobiol Dis 110:37-46 (2018). PubMed: 29107639
- Iderberg H et al. Modulating mGluR5 and 5-HT1A/1B receptors to treat l-DOPA-induced dyskinesia: effects of combined treatment and possible mechanisms of action. Exp Neurol 250:116-24 (2013). PubMed: 24029003