SKF 96365, TRP channel blocker (ab120280)
Key features and details
- Blocker of TRP cation channels. Inhibits capacitative Ca2+ entry.
- CAS Number: 130495-35-1
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SKF 96365, TRP channel blocker -
Description
Blocker of TRP cation channels. Inhibits capacitative Ca2+ entry. -
Biological description
Blocker of TRP cation channels. Inhibits capacitative Ca2+ entry.
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CAS Number
130495-35-1 -
Chemical structure
Properties
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Chemical name
1-[2-[3-(4-Methoxyphenyl)propoxy]-2-(4-methoxyphenyl)ethyl]-1H-imidazole hydrochloride -
Molecular weight
402.92 -
Molecular formula
C22H26N2O3.HCl -
PubChem identifier
104955 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.COc1ccc(cc1)C(OCCCc2ccc(OC)cc2)Cn3ccnc3 -
Source
Synthetic
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Research areas
Images
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Chemical Structure - SKF 96365, TRP channel blocker (ab120280)2D chemical structure image of ab120280, SKF 96365, TRP channel blocker
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Functional Studies - SKF 96365, TRP channel blocker (ab120280)Sansone et al PLoS One. 2014; 9(1): e87721. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/TRP channel blockers affect most of the L-arginine-induced responses.
L-arginine-induced Ca2+ responses of two ORNs of another individual slice of the lateral MOE (cyan and red trace). Incubation with SKF-96365 (80 µM; 10 min; lilac-shaded panel) led to a strong reduction of the Ca2+ transient in only one of the two ORNs (red trace). The response of the affected ORN recovered after 10 min of washout (right-hand traces). ORNs unaffected and affected by SKF-96365, expressed as percentage of total ORNs tested (histogram; 25 cells, 4 slices).
(From Figure 5C of Sansone et al).
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (16)
ab120280 has been referenced in 16 publications.
- Cheng P et al. Direct control of store-operated calcium channels by ultrafast laser. Cell Res 31:758-772 (2021). PubMed: 33469157
- Nascimento Da Conceicao V et al. Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics. iScience 24:103339 (2021). PubMed: 34816101
- Liu L et al. TRPC6 Attenuates Cortical Astrocytic Apoptosis and Inflammation in Cerebral Ischemic/Reperfusion Injury. Front Cell Dev Biol 8:594283 (2020). PubMed: 33604333
- Jiang C et al. VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine. Neuropsychopharmacology 44:971-981 (2019). PubMed: 30504797
- Chen J et al. Roles and mechanisms of TRPC3 and the PLC?/PKC/CPI-17 signaling pathway in regulating parturition. Mol Med Rep 17:898-910 (2018). PubMed: 29115500