SP600125, JNK inhibitor (ab120065)
Key features and details
- JNK inhibitor
- CAS Number: 129-56-6
- Soluble in DMSO to 100 mM and in ethanol to 5 mM (with heating)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SP600125, JNK inhibitor -
Description
JNK inhibitor -
Biological description
Potent and selective JNK1, -2, and -3 inhibitor (IC50 = 0.11 μM). SP600125 is a reversible ATP-competitive inhibitor with >20-fold selectivity over a range of kinases. It dose-dependently inhibits the phosphorylation of c-Jun and the expression of inflammatory genes COX-2, IL-2, IFNγ and TNFα. Neuroprotective in vivo.
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CAS Number
129-56-6 -
Chemical structure
Properties
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Chemical name
1,9-Pyrazoloanthrone -
Molecular weight
220.23 -
Molecular formula
C14H8N2O -
PubChem identifier
8515 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 5 mM (with heating) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C4c1cccc2nnc(c12)c3ccccc34 -
Source
Synthetic
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Research areas
Images
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Chemical Structure - SP600125, JNK inhibitor (ab120065)2D chemical structure image of ab120065, SP600125, JNK inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (37)
ab120065 has been referenced in 37 publications.
- Gao S et al. Effects of Holliday Junction-Recognition Protein-Mediated C-Jun N-Terminal Kinase/ Signal Transducer and Activator of Transcription 3 Signaling Pathway on Cell Proliferation, Cell Cycle and Cell Apoptosis in Bladder Urothelial Carcinoma. Tohoku J Exp Med 259:209-219 (2023). PubMed: 36543245
- Wang G et al. Exenatide exerts a neuroprotective effect against diabetic cognitive impairment in rats by inhibiting apoptosis: Role of the JNK/c-JUN signaling pathway. Mol Med Rep 25:N/A (2022). PubMed: 35119079
- Hu X et al. Operation of the Atypical Canonical Bone Morphogenetic Protein Signaling Pathway During Early Human Odontogenesis. Front Physiol 13:823275 (2022). PubMed: 35211032
- Ivshina MP et al. CPEB1 regulates the inflammatory immune response, phagocytosis, and alternative polyadenylation in microglia. Glia 70:1850-1863 (2022). PubMed: 35635122
- Fukami T et al. Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer. World J Gastroenterol 28:4649-4667 (2022). PubMed: 36157935