Spiperone hydrochloride, 5-HT and D2-like receptor antagonist (ab120549)
Key features and details
- 5-HT and D2-like receptor antagonist
- CAS Number: 2022-29-9
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Spiperone hydrochloride, 5-HT and D2-like receptor antagonist -
Description
5-HT and D2-like receptor antagonist -
Biological description
5-HT and D2-like receptor antagonist. (IC50 values are 1.6 and 15 nM at 5-HT2 and 5-HT1C receptors, respectively. Ki values are 0.06 ( D2), 0.6 (D3), 0.08 (D4), ~ 350 (D1) and ~ 3500 nM (D5)). Potently enhances intracellular Ca2+ levels. Additionally activates Ca2+-activated Cl- channels (CaCC) to induce Cl- secretion.
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CAS Number
2022-29-9 -
Chemical structure
Properties
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Chemical name
8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one hydrochloride -
Molecular weight
431.94 -
Molecular formula
C23H26FN3O2.HCl -
PubChem identifier
11957687 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Fc1ccc(cc1)C(=O)CCCN2CCC4(CC2)C(=O)NCN4c3ccccc3 -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Spiperone hydrochloride, 5-HT and D2-like receptor antagonist (ab120549)2D chemical structure image of ab120549, Spiperone hydrochloride, 5-HT and D2-like receptor antagonist
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Functional Studies - Spiperone hydrochloride, 5-HT and D2-like receptor antagonist (ab120549)Odaka et al PLoS One. 2014 Jun 10;9(6):e99271. doi: 10.1371/journal.pone.0099271. eCollection 2014. Fig 2. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Cabergoline exerted neuroprotective effect via D2 receptor-mediated mechanism.
(Panel B) Spiperone inhibited neuroprotection by cabergoline. Spiperone (10 µM) was applied 20 mins before cabergoline (10 µM) treatment, followed by MTT assay. The data represent mean ± SD (n = 6–12). ***P<0.001 vs. - H2O2 - Caber - spiperone, †††P<0.001 vs. + H2O2 - Caber - spiperone (three-way ANOVA).
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (2)
ab120549 has been referenced in 2 publications.
- Ward AH et al. Intravitreally-administered dopamine D2-like (and D4), but not D1-like, receptor agonists reduce form-deprivation myopia in tree shrews. Vis Neurosci 34:E003 (2017). PubMed: 28304244
- Odaka H et al. Cabergoline, dopamine D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity. PLoS One 9:e99271 (2014). PubMed: 24914776