SR95531 (Gabazine) (mM/ml), GABAA antagonist (ab144487)
Key features and details
- GABAA antagonist. 1 ml water soluble pack.
- CAS Number: 104104-50-9
- Purity: > 98%
- Soluble in 1 ml of water to give specified mM/ml concentration
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SR95531 (Gabazine) (mM/ml), GABAA antagonist -
Description
GABAA antagonist. 1 ml water soluble pack. -
Alternative names
- Gabazine
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Biological description
Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM.
Soluble in 1 ml water to give specified mM/ml concentration. Find out more. -
Purity
> 98% -
CAS Number
104104-50-9 -
Chemical structure
Properties
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Chemical name
2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide -
Molecular weight
368.23 -
Molecular formula
C15H17N3O3.HBr -
PubChem identifier
107895 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in 1 ml of water to give specified mM/ml concentration -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[Br-].COc1ccc(cc1)C=2C=CC(=[NH2+])N(CCCC(=O)O)N=2 -
Source
Synthetic
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Research areas
Images
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Chemical Structure - SR95531 (Gabazine) (mM/ml), GABAA antagonist (ab144487)2D chemical structure image of ab144487, SR95531 (Gabazine) (mM/ml), GABAA antagonist
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Functional Studies - SR95531 (Gabazine) (mM/ml), GABAA antagonist (ab144487)Errington et al PLoS One. 2011; 6(4): e19021. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Increased tonic GABA currents and altered IPSC properties in TC neurons of SSADH−/− mice.
C, representative current traces from thalamocortical neurons of WT (left) and SSADH−/− (right) mice showing the difference in tonic current amplitude between the two genotypes. Dotted lines represent the initial baseline current prior to the focal application of 50 µM GBZ (white bar).
GBZ = Gabazine.
(From Figure 1 of Erringtom et al).
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (56)
ab144487 has been referenced in 56 publications.
- Chen CR et al. Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in mice. Elife 10:N/A (2021). PubMed: 34787078
- Shi HY et al. Lesion of intergeniculate leaflet GABAergic neurons attenuates sleep in mice exposed to light. Sleep 43:N/A (2020). PubMed: 31552427
- Kim YS et al. Characterizing the conductance underlying depolarization-induced slow current in cerebellar Purkinje cells. J Neurophysiol 109:1174-81 (2013). PubMed: 23197456
- Griguoli M et al. In hippocampal oriens interneurons anti-Hebbian long-term potentiation requires cholinergic signaling via a7 nicotinic acetylcholine receptors. J Neurosci 33:1044-9 (2013). PubMed: 23325242
- Borisovska M et al. Distinct modes of dopamine and GABA release in a dual transmitter neuron. J Neurosci 33:1790-6 (2013). PubMed: 23365218