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    products/biochemicals/staurosporine-dmso-solution-protein-kinase-inhibitor-ab146588.pdf

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Cell Biology Apoptosis Intracellular Kinases
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Staurosporine (DMSO solution), protein kinase inhibitor (ab146588)

  • Datasheet
  • SDS
  • COA
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Chemical Structure - Staurosporine (DMSO solution), protein kinase inhibitor (ab146588)

    Key features and details

    • Protein kinase inhibitor
    • CAS Number: 62996-74-1
    • Purity: > 98%
    • Supplied in DMSO (1mM)
    • Form / State: Liquid
    • Source: Synthetic

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    Overview

    • Product name

      Staurosporine (DMSO solution), protein kinase inhibitor
    • Description

      Protein kinase inhibitor
    • Purity

      > 98%
    • CAS Number

      62996-74-1
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      [9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3,2,1-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
    • Molecular weight

      466.54
    • Molecular formula

      C28H26N4O3
    • PubChem identifier

      44259
    • Storage instructions

      Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
    • Solubility overview

      Supplied in DMSO (1mM)
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Toxic, refer to SDS for further information

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      O=C6NCc5c2c4n(c1ccccc12)[C@@]3(C)O[C@H](C[C@@H](NC)[C@H]3OC)n7c4c(c56)c8ccccc78
    • Source

      Synthetic

    • Research areas

      • Cell Biology
      • Apoptosis
      • Intracellular
      • Kinases
      • Signal Transduction
      • Protein Phosphorylation
      • Tyrosine Kinases
      • Src Family
      • Signal Transduction
      • Protein Phosphorylation
      • Ser / Thr Kinases
      • PKC
      • Signal Transduction
      • Signaling Pathway
      • Calcium Signaling
      • Other
      • Neuroscience
      • Neurology process
      • Neuroendocrinology
      • Prolactin
      • Neuroscience
      • Neurology process
      • Neurodegenerative disease
      • Other
      • Neuroscience
      • Neurology process
      • Growth and Development
      • Axonal Guidance Proteins
      • Neuroscience
      • Neurology process
      • Neurogenesis
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Cancer susceptibility
      • Proto-oncogenes
      • Cancer
      • Signal transduction
      • Protein phosphorylation
      • Serine/threonine kinases
      • MAPK pathway
      • Cancer
      • Signal transduction
      • Protein phosphorylation
      • Tyrosine kinases
      • Src family
      • Cardiovascular
      • Heart
      • Hypertrophy
      • Other
      • Cancer
      • Cancer Metabolism
      • Response to hypoxia
      • Metabolism
      • Pathways and Processes
      • Metabolism processes
      • Hypoxia

    Images

    • Chemical Structure - Staurosporine (DMSO solution), protein kinase inhibitor (ab146588)
      Chemical Structure - Staurosporine (DMSO solution), protein kinase inhibitor (ab146588)
      2D chemical structure image of ab146588, Staurosporine (DMSO solution), protein kinase inhibitor

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (3)

    Publishing research using ab146588? Please let us know so that we can cite the reference in this datasheet.

    ab146588 has been referenced in 3 publications.

    • O'Callaghan P  et al. Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells. J Cell Sci 135:N/A (2022). PubMed: 35274124
    • Akande OE  et al. DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination. Cell Rep 26:3323-3335.e4 (2019). PubMed: 30893604
    • Lynch JM  et al. Mutant myocilin impacts sarcomere ultrastructure in mouse gastrocnemius muscle. PLoS One 13:e0206801 (2018). PubMed: 30395621

    Customer reviews and Q&As

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