SU 1498, VEGFR2 inhibitor (ab141447)
Key features and details
- Selective VEGFR2 inhibitor
- CAS Number: 168835-82-3
- Purity: > 99%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SU 1498, VEGFR2 inhibitor -
Description
Selective VEGFR2 inhibitor -
Purity
> 99% -
General notes
It is important to note that this product has been reported to be unstable under a variety of conditions. In addition to being unstable to light and air after extended periods of time, this product is extremely unstable in polar solvents such as DMSO. Within 1 hour a DMSO solution showed signs of decomposition. We therefore recommend this material is only stored as the solid form at -20°C (or below), with the exclusion of light and air, and any solutions are made up fresh and used immediately
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CAS Number
168835-82-3 -
Chemical structure
Properties
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Chemical name
(E)-2-Cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-2-propenamide -
Molecular weight
390.52 -
Molecular formula
C25H30N2O2 -
PubChem identifier
5941539 -
Storage instructions
Store at -20°C. Please see notes section. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 100 mM -
Handling
Unstable; make up solutions fresh and use immediately.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)C1=CC(=CC(=C1O)C(C)C)C=C(C#N)C(=O)NCCCC2=CC=CC=C2 -
Source
Synthetic
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Research areas
Images
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Chemical Structure - SU 1498, VEGFR2 inhibitor (ab141447)2D chemical structure image of ab141447, SU 1498, VEGFR2 inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (3)
ab141447 has been referenced in 3 publications.
- Xu H et al. ADAMTS13 controls vascular remodeling by modifying VWF reactivity during stroke recovery. Blood 130:11-22 (2017). PubMed: 28428179
- Wang X et al. P18 peptide, a functional fragment of pigment epithelial-derived factor, inhibits angiogenesis in hepatocellular carcinoma via modulating VEGF/VEGFR2 signalling pathway. Oncol Rep 38:755-766 (2017). PubMed: 28627623
- Lin Y et al. Autocrine VEGF signaling promotes cell proliferation through a PLC-dependent pathway and modulates Apatinib treatment efficacy in gastric cancer. Oncotarget 8:11990-12002 (2017). PubMed: 28061477