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    products/biochemicals/su-1498-vegfr2-inhibitor-ab141447.pdf

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Cardiovascular Angiogenesis Growth Factors VEGF VEGF Receptors
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SU 1498, VEGFR2 inhibitor (ab141447)

  • Datasheet
  • SDS
  • COA
Submit a review Submit a question References (3)

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Chemical Structure - SU 1498, VEGFR2 inhibitor (ab141447)

    Key features and details

    • Selective VEGFR2 inhibitor
    • CAS Number: 168835-82-3
    • Purity: > 99%
    • Soluble in ethanol to 100 mM and in DMSO to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      SU 1498, VEGFR2 inhibitor
    • Description

      Selective VEGFR2 inhibitor
    • Purity

      > 99%
    • General notes

      It is important to note that this product has been reported to be unstable under a variety of conditions. In addition to being unstable to light and air after extended periods of time, this product is extremely unstable in polar solvents such as DMSO. Within 1 hour a DMSO solution showed signs of decomposition. We therefore recommend this material is only stored as the solid form at -20°C (or below), with the exclusion of light and air, and any solutions are made up fresh and used immediately

    • CAS Number

      168835-82-3
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      (E)-2-Cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-2-propenamide
    • Molecular weight

      390.52
    • Molecular formula

      C25H30N2O2
    • PubChem identifier

      5941539
    • Storage instructions

      Store at -20°C. Please see notes section. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
    • Solubility overview

      Soluble in ethanol to 100 mM and in DMSO to 100 mM
    • Handling

      Unstable; make up solutions fresh and use immediately.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CC(C)C1=CC(=CC(=C1O)C(C)C)C=C(C#N)C(=O)NCCCC2=CC=CC=C2
    • Source

      Synthetic

    • Research areas

      • Cardiovascular
      • Angiogenesis
      • Growth Factors
      • VEGF
      • VEGF Receptors
      • Microbiology
      • Interspecies Interaction
      • Host Virus Interaction
      • Epigenetics and Nuclear Signaling
      • DNA / RNA
      • DNA Synthesis
      • Topoisomerases
      • Signal Transduction
      • Protein Phosphorylation
      • Tyrosine Kinases
      • Receptor Tyrosine Kinases
      • Signal Transduction
      • Growth Factors/Hormones
      • VEGF
      • Stem Cells
      • Hematopoietic Progenitors
      • Surface Molecules
      • Cancer
      • Growth factors
      • VEGF
      • Cancer
      • Invasion/microenvironment
      • Angiogenesis
      • Angiogenic growth factors
      • Cancer
      • Oncoproteins/suppressors
      • Oncoproteins
      • Growth factor receptors
      • Stem Cells
      • Endothelial Progenitors
      • Endothelial Markers
      • Cancer
      • Cancer Metabolism
      • Response to hypoxia
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Enzyme-Linked Receptors
      • Receptor tyrosine kinases
      • VEGFR
      • Cardiovascular
      • Cardiovascular Markers
      • Cell Markers
      • Endothelial Cells
      • Metabolism
      • Pathways and Processes
      • Metabolism processes
      • Hypoxia
      • Biochemicals
      • Pharmacology
      • Signaling
      • Apoptosis & cell cycle
      • Growth factors
      • VEGFR
      • Biochemicals
      • Research Area
      • Cancer
      • Apoptosis & cell cycle
      • Growth factors
      • VEGFR
      • Biochemicals
      • Pharmacology
      • Enzymes
      • Kinase
      • Tyrosine Kinase
      • Receptor Tyrosine Kinase
      • VEGFR
      • Biochemicals
      • Pharmacology
      • Signaling
      • Stem Cells
      • Growth factors
      • Biochemicals
      • Research Area
      • Stem Cells
      • Growth factors
      • Cardiovascular
      • Angiogenesis
      • Endothelial Cell Markers

    Images

    • Chemical Structure - SU 1498, VEGFR2 inhibitor (ab141447)
      Chemical Structure - SU 1498, VEGFR2 inhibitor (ab141447)
      2D chemical structure image of ab141447, SU 1498, VEGFR2 inhibitor

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (3)

    Publishing research using ab141447? Please let us know so that we can cite the reference in this datasheet.

    ab141447 has been referenced in 3 publications.

    • Xu H  et al. ADAMTS13 controls vascular remodeling by modifying VWF reactivity during stroke recovery. Blood 130:11-22 (2017). PubMed: 28428179
    • Wang X  et al. P18 peptide, a functional fragment of pigment epithelial-derived factor, inhibits angiogenesis in hepatocellular carcinoma via modulating VEGF/VEGFR2 signalling pathway. Oncol Rep 38:755-766 (2017). PubMed: 28627623
    • Lin Y  et al. Autocrine VEGF signaling promotes cell proliferation through a PLC-dependent pathway and modulates Apatinib treatment efficacy in gastric cancer. Oncotarget 8:11990-12002 (2017). PubMed: 28061477

    Customer reviews and Q&As

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