Sulindac sulfide, COX-1 and 2 inhibitor (ab120650)
Key features and details
- Active metabolite of Sulindac. COX-1 and 2 inhibitor.
- CAS Number: 32004-67-4
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Sulindac sulfide, COX-1 and 2 inhibitor -
Description
Active metabolite of Sulindac. COX-1 and 2 inhibitor. -
Biological description
Cell-permeable, active metabolite of Sulindac. Inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. COX-1 and 2 inhibitor (Ki values are 1.02 and 10.43 μM, respectively). Additionally, inhibits γ-secretase. Apoptosis inducer.
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Purity
> 98% -
CAS Number
32004-67-4 -
Chemical structure
Properties
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Chemical name
(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid -
Molecular weight
340.41 -
Molecular formula
C20H17FO2S -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
Images
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Chemical Structure - Sulindac sulfide, COX-1 and 2 inhibitor (ab120650)2D chemical structure image of ab120650, Sulindac sulfide, COX-1 and 2 inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (0)
ab120650 has not yet been referenced specifically in any publications.