Tetrodotoxin citrate, Na+ channel blocker (ab120055)
Key features and details
- Na+ channel blocker; water-soluble
- CAS Number: 18660-81-6
Soluble in water
- Form / State: Solid
- Source: Fugu
Overview
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Product name
Tetrodotoxin citrate, Na+ channel blocker -
Description
Na+ channel blocker; water-soluble -
Alternative names
- TTX
- TTX citrate
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Biological description
Water soluble citrate salt of tetrodotoxin. Potent, selective and reversible, use-dependent inhibitor of voltage-dependent Na+ channels.
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General notes
The vial will contain 1 mg of TTX and an additional 5 mg of citrate buffer to aid with solubility. For calculations relating to TTX concentration, refer to the molecular weight 319.27 listed on the vial.
Item is subject to Export Control Regulations and Licensing requirements. Please contact Customer Service for more information and lead times.
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CAS Number
18660-81-6 -
Chemical structure
Properties
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Chemical name
Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d] pyrimidine-4,7,10,11,12-pentol + citrate buffer
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Molecular weight
511.40 -
Molecular formula
C11H17N3O8.C6H8O7 -
PubChem identifier
205806 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(O)C(O)(CC(=O)O)CC(=O)O.O[C@H]3C14NC(=N)N[C@H](O)[C@@H]4C2O[C@]3(O)O[C@H](C1O)C2(O)CO -
Source
Fugu
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Research areas
Images
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Chemical Structure - Tetrodotoxin citrate, Na+ channel blocker (ab120055)2D chemical structure image of ab120055, Tetrodotoxin citrate, Na+ channel blocker
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Functional Studies - Tetrodotoxin citrate, Na+ channel blocker (ab120055)Marion and Hay PLoS One. 2011;6(12):e27581. doi: 10.1371/journal.pone.0027581. Epub 2011 Dec 2. Fig 5. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Percent of TTX-containing food pellets eaten by bluegill over 6 d of repeated feedings.
Pellets were infused with different concentrations of TTX within the range found in newts from the field. P values are from likelihood ratio tests from a GLMM.
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Functional Studies - Tetrodotoxin citrate, Na+ channel blocker (ab120055)Image from Bertran-Gonzalez J et al., PLoS One. 2012;7(12):e53195. Fig 3(A).; doi: 10.1371/journal.pone.0053195. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Cell-attached recording of a striatal cholinergic interneuron depicting TTX (100 nM) inhibition of spontaneous action potential firing. The open bar indicates time of TTX application. -
Functional Studies - Tetrodotoxin citrate, Na+ channel blocker (ab120055)Image from Bertran-Gonzalez J et al., PLoS One. 2012;7(12):e53195. Fig 3(C).; doi: 10.1371/journal.pone.0053195.Quantification of the p-S6rp signal in each striatal ChAt immunoreactive neuron after 1 hour incubation in control or TTX (1 M). Each dot corresponds to one neuron; each color corresponds to a different animal; dashed lines indicate the mean. Fluorescence values are normalized in arbitrary units (a.u.).
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (129)
ab120055 has been referenced in 129 publications.
- Retailleau K et al. The Isolated Mouse Jejunal Afferent Nerve Assay as a Tool to Assess the Effect of Botulinum Neurotoxins in Visceral Nociception. Toxins (Basel) 14:N/A (2022). PubMed: 35324702
- Dingle YL et al. Integrated functional neuronal network analysis of 3D silk-collagen scaffold-based mouse cortical culture. STAR Protoc 2:100292 (2021). PubMed: 33537680
- Acuña-Hinrichsen F et al. Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines. Front Cell Neurosci 15:580717 (2021). PubMed: 33708072
- Hughson BN et al. AKH Signaling in D. melanogaster Alters Larval Development in a Nutrient-Dependent Manner That Influences Adult Metabolism. Front Physiol 12:619219 (2021). PubMed: 33708137
- Chang DF et al. NH2-terminal deletion of specific phosphorylation sites on PHOX2B disrupts the formation of enteric neurons in vivo. Am J Physiol Gastrointest Liver Physiol 320:G1054-G1066 (2021). PubMed: 33881351