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    products/biochemicals/tetrodotoxin-citrate-na-channel-blocker-ab120055.pdf

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Biochemicals Product Range Just Add Water
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Tetrodotoxin citrate, Na+ channel blocker (ab120055)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (3)References (129)

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Chemical Structure - Tetrodotoxin citrate, Na<sup>+</sup> channel blocker (ab120055)
  • Functional Studies - Tetrodotoxin citrate, Na<sup>+</sup> channel blocker (ab120055)
  • Functional Studies - Tetrodotoxin citrate, Na<sup>+</sup> channel blocker (ab120055)
  • Functional Studies - Tetrodotoxin citrate, Na<sup>+</sup> channel blocker (ab120055)

Key features and details

  • Na+ channel blocker; water-soluble
  • CAS Number: 18660-81-6
  • Soluble in water

  • Form / State: Solid
  • Source: Fugu

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Overview

  • Product name

    Tetrodotoxin citrate, Na+ channel blocker
  • Description

    Na+ channel blocker; water-soluble
  • Alternative names

    • TTX
    • TTX citrate
  • Biological description

    Water soluble citrate salt of tetrodotoxin. Potent, selective and reversible, use-dependent inhibitor of voltage-dependent Na+ channels.

  • General notes

    The vial will contain 1 mg of TTX and an additional 5 mg of citrate buffer to aid with solubility. For calculations relating to TTX concentration, refer to the molecular weight 319.27 listed on the vial.

    Item is subject to Export Control Regulations and Licensing requirements. Please contact Customer Service for more information and lead times.

  • CAS Number

    18660-81-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d] pyrimidine-4,7,10,11,12-pentol + citrate buffer

  • Molecular weight

    511.40
  • Molecular formula

    C11H17N3O8.C6H8O7
  • PubChem identifier

    205806
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(O)C(O)(CC(=O)O)CC(=O)O.O[C@H]3C14NC(=N)N[C@H](O)[C@@H]4C2O[C@]3(O)O[C@H](C1O)C2(O)CO
  • Source

    Fugu

  • Research areas

    • Biochemicals
    • Product Range
    • Just Add Water
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Chemical Type
    • Toxin
    • Biochemicals
    • Pharmacology
    • Ion Channels
    • Sodium
    • Blockers
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    • Research Area
    • Diabetes
    • Sodium
    • Blockers
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    • Research Area
    • Heart disease
    • Sodium
    • Blockers
    • Biochemicals
    • Research Area
    • Hypertension
    • Sodium
    • Blockers
    • Biochemicals
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    • Obesity
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    • Pain & inflammation
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    • Blockers
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Sodium
    • Blockers
    • Biochemicals
    • Research Area
    • Stroke
    • Sodium
    • Blockers

Images

  • Chemical Structure - Tetrodotoxin citrate, Na<sup>+</sup> channel blocker (ab120055)
    Chemical Structure - Tetrodotoxin citrate, Na+ channel blocker (ab120055)
    2D chemical structure image of ab120055, Tetrodotoxin citrate, Na+ channel blocker
  • Functional Studies - Tetrodotoxin citrate, Na<sup>+</sup> channel blocker (ab120055)
    Functional Studies - Tetrodotoxin citrate, Na+ channel blocker (ab120055)Marion and Hay PLoS One. 2011;6(12):e27581. doi: 10.1371/journal.pone.0027581. Epub 2011 Dec 2. Fig 5. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

    Percent of TTX-containing food pellets eaten by bluegill over 6 d of repeated feedings.

    Pellets were infused with different concentrations of TTX within the range found in newts from the field. P values are from likelihood ratio tests from a GLMM.

  • Functional Studies - Tetrodotoxin citrate, Na<sup>+</sup> channel blocker (ab120055)
    Functional Studies - Tetrodotoxin citrate, Na+ channel blocker (ab120055)Image from Bertran-Gonzalez J et al., PLoS One. 2012;7(12):e53195. Fig 3(A).; doi: 10.1371/journal.pone.0053195. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/
    Cell-attached recording of a striatal cholinergic interneuron depicting TTX (100 nM) inhibition of spontaneous action potential firing. The open bar indicates time of TTX application.
  • Functional Studies - Tetrodotoxin citrate, Na<sup>+</sup> channel blocker (ab120055)
    Functional Studies - Tetrodotoxin citrate, Na+ channel blocker (ab120055)Image from Bertran-Gonzalez J et al., PLoS One. 2012;7(12):e53195. Fig 3(C).; doi: 10.1371/journal.pone.0053195.
    Quantification of the p-S6rp signal in each striatal ChAt immunoreactive neuron after 1 hour incubation in control or TTX (1 M). Each dot corresponds to one neuron; each color corresponds to a different animal; dashed lines indicate the mean. Fluorescence values are normalized in arbitrary units (a.u.).

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (129)

Publishing research using ab120055? Please let us know so that we can cite the reference in this datasheet.

ab120055 has been referenced in 129 publications.

  • Retailleau K  et al. The Isolated Mouse Jejunal Afferent Nerve Assay as a Tool to Assess the Effect of Botulinum Neurotoxins in Visceral Nociception. Toxins (Basel) 14:N/A (2022). PubMed: 35324702
  • Dingle YL  et al. Integrated functional neuronal network analysis of 3D silk-collagen scaffold-based mouse cortical culture. STAR Protoc 2:100292 (2021). PubMed: 33537680
  • Acuña-Hinrichsen F  et al. Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines. Front Cell Neurosci 15:580717 (2021). PubMed: 33708072
  • Hughson BN  et al. AKH Signaling in D. melanogaster Alters Larval Development in a Nutrient-Dependent Manner That Influences Adult Metabolism. Front Physiol 12:619219 (2021). PubMed: 33708137
  • Chang DF  et al. NH2-terminal deletion of specific phosphorylation sites on PHOX2B disrupts the formation of enteric neurons in vivo. Am J Physiol Gastrointest Liver Physiol 320:G1054-G1066 (2021). PubMed: 33881351
View all Publications for this product

Customer reviews and Q&As

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1-3 of 3 Abreviews or Q&A

Question

What is the molecular weight of tetrodotoxin citrate? The datasheets for this product, ab120055, and tetrodotoxin, ab120054, give the same molecular weight (319.27) and same molecular formula (C11H17N3O8).

Read More

Abcam community

Verified customer

Asked on Jun 14 2013

Answer

The water-soluble TTX citrate ab120055 is not a citrate salt, it is simply TTX that has been dissolved in a citrate solution, and then lyophilized. So, it has the same molecular weight and formula as ab120054, which is soluble in pH 4.8 citrate buffer to 100 mM.

Read More

Tom Ruyle

Abcam Scientific Support

Answered on Jun 14 2013

Question

Customer kindly contacted us regarding the difference between ab1202054 (TTX) and ab120055 (TTX-Citrate).

Read More

Abcam community

Verified customer

Asked on Jan 14 2013

Answer


I contacted the laboratory regarding the difference between ab120054 and ab120055, and they responded that the only difference between these two compounds is that TTX citrate (ab120055) is the water soluble version, which accounts for the difference in price.

Read More

Abcam Scientific Support

Answered on Jan 14 2013

Question

What are the proper disposal procedures for ab120055, and how should it be neutralized in case of a spill?

Read More

Abcam community

Verified customer

Asked on Dec 17 2012

Answer

Tetrodotoxin is very toxic and should be handled with caution. The safety datasheet is available from the datasheet.

Additionally, to neutralize the toxin, you may use a freshly made solution of 0.25% NaOCl + 0.25 N NaOH or a solution of 0.5% NaOCl. Allow a 30 minute contact time. The spill must then cleaned up using absorbent material. The area must be further washed using a soapy solution to remove any residues. The spill material should be collected and disposed of as hazardous waste.

Read More

Abcam Scientific Support

Answered on Dec 17 2012

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