TOFA (5-(tetradecyloxy)-2-furoic acid), acetyl-CoA carboxylase inhibitor. (ab141578)
Key features and details
- Potent, reversible and competitive acetyl-CoA carboxylase inhibitor.
- CAS Number: 54857-86-2
- Purity: > 99%
- Soluble in DMSO to 25 mM and in ethanol
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
TOFA (5-(tetradecyloxy)-2-furoic acid), acetyl-CoA carboxylase inhibitor. -
Description
Potent, reversible and competitive acetyl-CoA carboxylase inhibitor. -
Biological description
Potent, reversible, competitive acetyl-CoA carboxylase (ACC) inhibitor.
Hypolipidemic agent, active in vivo. Cell-permeable. -
Purity
> 99% -
CAS Number
54857-86-2 -
Chemical structure
Properties
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Chemical name
5-Tetradecoxyfuran-2-carboxylic acid -
Molecular weight
324.50 -
Molecular formula
C19H32O4 -
PubChem identifier
115175 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM and in ethanol -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCCCCCCCCCCCCCOC1=CC=C(O1)C(=O)O -
Source
Synthetic
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Research areas
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (6)
ab141578 has been referenced in 6 publications.
- Liu S et al. Acetyl-CoA carboxylase 1 depletion suppresses de novo fatty acid synthesis and mitochondrial β-oxidation in castration-resistant prostate cancer cells. J Biol Chem 299:102720 (2023). PubMed: 36410440
- Veprik A et al. Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion. Commun Biol 5:238 (2022). PubMed: 35304577
- Miralpeix C et al. Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status. Br J Pharmacol 178:1507-1523 (2021). PubMed: 33444462
- Casas M et al. Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking. J Cell Biol 219:N/A (2020). PubMed: 32931550
- Palomo-Guerrero M et al. Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth. Elife 8:N/A (2019). PubMed: 31868590
- Lee JH et al. RNF20 Suppresses Tumorigenesis by Inhibiting SREBP1c-PTTG1 Axis in Kidney Cancer. Mol Cell Biol N/A:N/A (2017). PubMed: 28827316