UBP310, GluK1 and GluK3 selective antagonist (ab120168)
Key features and details
- GluK1 and GluK3 selective antagonist
- CAS Number: 902464-46-4
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
UBP310, GluK1 and GluK3 selective antagonist -
Description
GluK1 and GluK3 selective antagonist -
Biological description
GluK1 (formerly GluR5) and GluK3 (formerly GluR7) receptor selective antagonist (Kb =10 nM and IC50 = 23 nM, respectively). IC50 values are >100 μM at recombinant human GLUA2 (formerly GluR2), GluK2 (formerly GluR6,) GluK2/GluK5 (formerly GluR6/KA2) and GluK2/GluK3 (formerly GluR6/GluR7). Selective over native AMPA receptors (Kd = 83 μM) and exhibits no activity at NMDA and Group I mGlu receptors at concentrations of up to 10 µM.
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Purity
> 98% -
CAS Number
902464-46-4 -
Chemical structure
Properties
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Chemical name
(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxythiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione -
Molecular weight
353.35 -
Molecular formula
C14H15N3O6S -
PubChem identifier
6420160 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(O)[C@@H](N)CN2C=C(C)C(=O)N(Cc1ccsc1C(=O)O)C2=O -
Source
Synthetic
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Research areas
Images
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Chemical Structure - UBP310, GluK1 and GluK3 selective antagonist (ab120168)2D chemical structure image of ab120168, UBP310, GluK1 and GluK3 selective antagonist
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (3)
ab120168 has been referenced in 3 publications.
- Lindstrom SH et al. Kainate receptor subunit diversity underlying response diversity in retinal Off bipolar cells. J Physiol 592:1457-77 (2014). PubMed: 24396054
- Puthussery T et al. Kainate receptors mediate synaptic input to transient and sustained OFF visual pathways in primate retina. J Neurosci 34:7611-21 (2014). PubMed: 24872565
- Atlason PT et al. Mapping the ligand binding sites of kainate receptors: molecular determinants of subunit-selective binding of the antagonist [3H]UBP310. Mol Pharmacol 78:1036-45 (2010). PubMed: 20837679