Key features and details
- Novel, selective, cell permeable p21 inhibitor
- CAS Number: 1394011-91-6
- Purity: > 98%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameUC2288, p21 inhibitor
DescriptionNovel, selective, cell permeable p21 inhibitor
- p21/Cip1/CKI/Waf1 Inhibitor
Cell-permeable, phenylcyclohexyl-urea based compound that selectively downregulates the expression of p21, independent of p53 expression, at either transcription or post-transcriptional level. Attenuates p21 protein levels with minimal effect on p21 protein stability. Has no significant effect on the activities of Raf kinases, VEGFR2 kinase, or the phosphorylation state of ERK. Effectively inhibits the growth of multiple cancer cell lines (GI50 = ~ 10 µM against NCI60 cell lines).
Storage instructionsShipped at Room Temperature. Store at +4°C. Store In the Dark.
Solubility overviewSoluble in ethanol to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146969 has been referenced in 4 publications.
- Lu J et al. Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation. Invest Ophthalmol Vis Sci 63:18 (2022). PubMed: 35472217
- Huang S et al. Obg-like ATPase 1 (OLA1) overexpression predicts poor prognosis and promotes tumor progression by regulating P21/CDK2 in hepatocellular carcinoma. Aging (Albany NY) 12:3025-3041 (2020). PubMed: 32045367
- Pisonero-Vaquero S et al. TFEB Modulates p21/WAF1/CIP1 during the DNA Damage Response. Cells 9:N/A (2020). PubMed: 32397616
- Tay VSY et al. Increased double strand breaks in diabetic ß-cells with a p21 response that limits apoptosis. Sci Rep 9:19341 (2019). PubMed: 31852915