UCPH-101, Selective EAAT1 inhibitor (ab120309)
Key features and details
- Selective EAAT1 inhibitor
- CAS Number: 1118460-77-7
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
UCPH-101, Selective EAAT1 inhibitor -
Description
Selective EAAT1 inhibitor -
Biological description
Selective inhibitor of EAAT1 (IC50 = 0.67 μM). Displays >400-fold selectivity over EAAT2 and EAAT3.
Blood-brain barrier permeable analog UCPH-102 also available (ab146404). -
CAS Number
1118460-77-7 -
Chemical structure
Properties
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Chemical name
2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile -
Molecular weight
422.48 -
Molecular formula
C27H22N2O3 -
PubChem identifier
25223366 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COc1ccc(cc1)C2C=3C(=O)CC(CC=3OC(N)=C2C#N)c5cccc4ccccc45 -
Source
Synthetic
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Research areas
Images
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Chemical Structure - UCPH-101, Selective EAAT1 inhibitor (ab120309)2D chemical structure image of ab120309, UCPH-101, Selective EAAT1 inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (6)
ab120309 has been referenced in 6 publications.
- Haym I et al. Bioavailability Studies and in vitro Profiling of the Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitor UCPH-102. ChemMedChem N/A:N/A (2016). PubMed: 26797816
- Yang Y & Xu-Friedman MA Different pools of glutamate receptors mediate sensitivity to ambient glutamate in the cochlear nucleus. J Neurophysiol 113:3634-45 (2015). PubMed: 25855696
- Morioka N et al. Primary cultures of rat cortical microglia treated with nicotine increases in the expression of excitatory amino acid transporter 1 (GLAST) via the activation of the a7 nicotinic acetylcholine receptor. Neuroscience 258:374-84 (2014). PubMed: 24300109
- Budisantoso T et al. Mechanisms underlying signal filtering at a multisynapse contact. J Neurosci 32:2357-76 (2012). PubMed: 22396411
- Uwechue NM et al. Activation of glutamate transport evokes rapid glutamine release from perisynaptic astrocytes. J Physiol 590:2317-31 (2012). PubMed: 22411007
- Salvatore MF et al. Transient striatal GLT-1 blockade increases EAAC1 expression, glutamate reuptake, and decreases tyrosine hydroxylase phosphorylation at ser(19). Exp Neurol 234:428-36 (2012). PubMed: 22285253