Wortmannin, PI3-kinase inhibitor (ab120148)
Key features and details
- PI3-kinase inhibitor
- CAS Number: 19545-26-7
- Purity: > 98%
- Soluble in DMSO to 50 mM and in ethanol to 5 mM
- Form / State: Solid
- Source: Penicillium funiculosum
Overview
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Product name
Wortmannin, PI3-kinase inhibitor -
Description
PI3-kinase inhibitor -
Biological description
Potent, selective and cell-permeable inhibitor of phosphatidylinositol-3-kinase (PI3-kinase) (IC50 ~ 3 nM)
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Purity
> 98% -
CAS Number
19545-26-7 -
Chemical structure
Properties
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Chemical name
(1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,h]-2-h]-2-benzopyran-3,6,9-trione -
Molecular weight
428.44 -
Molecular formula
C23H24O8 -
PubChem identifier
312145 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM and in ethanol to 5 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=O)O[C@@H]4C[C@]5(C)C(=O)CC[C@H]5C=3C(=O)c2occ1C(=O)O[C@H](COC)[C@@](C)(c12)C=34 -
Source
Penicillium funiculosum
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Research areas
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- PI3K/Akt signaling
- PI3-kinase
- Inhibitors
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- PI3K/Akt signaling
- PI3-kinase
- Inhibitors
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- PI3K/Akt signaling
- PI3-kinase
- Inhibitors
- Biochemicals
- Research Area
- Obesity
- Signaling
- Signal transduction
- PI3K/Akt signaling
- PI3-kinase
- Inhibitors
Images
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Chemical Structure - Wortmannin, PI3-kinase inhibitor (ab120148)2D chemical structure image of ab120148, Wortmannin, PI3-kinase inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (15)
ab120148 has been referenced in 15 publications.
- Zhang MH & Liu J Cleavage stimulation factor 2 promotes malignant progression of liver hepatocellular carcinoma by activating phosphatidylinositol 3'-kinase/protein kinase B/mammalian target of rapamycin pathway. Bioengineered 13:10047-10060 (2022). PubMed: 35412944
- Lee JH et al. n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway. Int J Mol Sci 22:N/A (2021). PubMed: 34199295
- Chen S et al. Ginsenoside metabolite 20(S)-protopanaxadiol promotes neural stem cell transition from a state of proliferation to differentiation by inducing autophagy and cell cycle arrest. Mol Med Rep 22:353-361 (2020). PubMed: 32319663
- Martin-Gallausiaux C et al. Fusobacterium nucleatum Extracellular Vesicles Modulate Gut Epithelial Cell Innate Immunity via FomA and TLR2. Front Immunol 11:583644 (2020). PubMed: 33408714
- Gamero-Estevez E et al. Temporal Effects of Quercetin on Tight Junction Barrier Properties and Claudin Expression and Localization in MDCK II Cells. Int J Mol Sci 20:N/A (2019). PubMed: 31581662