Key features and details
- Potent, selective mGlu1 antagonist
- CAS Number: 748758-45-4
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameYM298198 hydrochloride, mGlu1 antagonist
DescriptionPotent, selective mGlu1 antagonist
Potent, selective, water-soluble, non-competitive mGlu1 antagonist (IC50 = 16 nM) Selective over mGlu2,3,4,5,6, and 7 and ionotropic receptors (IC50 > 10 μM). Orally active analgesic in vivo.
Also available in simple stock solutions (ab146667) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical name6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120015 has been referenced in 5 publications.
- Biever A et al. PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons. J Neurosci 35:4113-30 (2015). PubMed: 25762659
- Tian J et al. Dual depolarization responses generated within the same lateral septal neurons by TRPC4-containing channels. Pflugers Arch 466:1301-16 (2014). Mouse . PubMed: 24121765
- Zhang L & Alger BE Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome. J Neurosci 30:5724-9 (2010). PubMed: 20410124
- Jo J et al. Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95. Nat Neurosci 13:1216-24 (2010). PubMed: 20852624
- Lafourcade CA et al. Novel mGluR- and CB1R-independent suppression of GABA release caused by a contaminant of the group I metabotropic glutamate receptor agonist, DHPG. PLoS One 4:e6122 (2009). PubMed: 19568435