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    products/biochemicals/z-ietd-fmk-caspase-8-inhibitor-ab141382.pdf

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Cell Biology Apoptosis Intracellular Caspases etc Caspases
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Z-IETD-FMK, Caspase-8 inhibitor (ab141382)

  • Datasheet
  • SDS
Submit a review Submit a question References (5)

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Chemical Structure - Z-IETD-FMK, Caspase-8 inhibitor (ab141382)
  • Functional Studies - Z-IETD-FMK, Caspase-8 inhibitor (ab141382)

Key features and details

  • Caspase-8 inhibitor
  • CAS Number:
  • Purity: > 99%
  • Form / State: Lyophilized
  • Source: Synthetic

Overview

  • Product name

    Z-IETD-FMK, Caspase-8 inhibitor
  • Description

    Caspase-8 inhibitor
  • Purity

    > 99%
  • General notes

    This product is manufactured by BioVision, an Abcam company and was previously called 1148 IETD-FMK, Z-,. 1148-5 is the same size as the 5 mg size of ab141382.

  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    654.70
  • Molecular formula

    C30H43FN4O11
  • Sequence

    IETD (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK; Glu-2 = Glu(OMe); Asp-4 = Asp(OMe))
  • PubChem identifier

    44135212
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC(C)C(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)O)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O) OCC1=CC=CC=C1
  • Source

    Synthetic

  • Research areas

    • Cell Biology
    • Apoptosis
    • Intracellular
    • Caspases etc
    • Caspases
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Chemical Type
    • Bioactive peptides
    • Biochemicals
    • Pharmacology
    • Enzymes
    • Caspase
    • Biochemicals
    • Pharmacology
    • Signaling
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Heart disease
    • Signaling
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Signaling
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Signaling
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Signaling
    • Signal transduction
    • Hedgehog signaling
    • Smoothened
    • Biochemicals
    • Research Area
    • Cancer
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Diabetes
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Diabetes
    • Signaling
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Diabetes
    • Signaling
    • Signal transduction
    • Hedgehog signaling
    • Smoothened
    • Biochemicals
    • Research Area
    • Heart disease
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Hypertension
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Hypertension
    • Signaling
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Hypertension
    • Signaling
    • Signal transduction
    • Hedgehog signaling
    • Smoothened
    • Biochemicals
    • Research Area
    • Obesity
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Obesity
    • Signaling
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Obesity
    • Signaling
    • Signal transduction
    • Hedgehog signaling
    • Smoothened
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Signaling
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Stroke
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Stroke
    • Signaling
    • Apoptosis & cell cycle
    • Caspase
    • Biochemicals
    • Research Area
    • Stroke
    • Signaling
    • Signal transduction
    • Hedgehog signaling
    • Smoothened

Associated products

  • Related Products

    • Caspase-8 Assay Kit (Fluorometric) (ab39534)
    • Caspase-8 Assay Kit (Colorimetric) (ab39700)
    • Caspase-8 (active) FITC Staining Kit (ab65614)
    • Caspase-8 Inhibitor Assay Kit (ab102496)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab141382 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.
Notes
Functional Studies
Use at an assay dependent concentration.

Images

  • Chemical Structure - Z-IETD-FMK, Caspase-8 inhibitor (ab141382)
    Chemical Structure - Z-IETD-FMK, Caspase-8 inhibitor (ab141382)
    2D chemical structure image of ab141382, Z-IETD-FMK, Caspase-8 inhibitor
  • Functional Studies - Z-IETD-FMK, Caspase-8 inhibitor (ab141382)
    Functional Studies - Z-IETD-FMK, Caspase-8 inhibitor (ab141382)
    ab13847 staining active caspase 3 in SKNSH cells treated with Z-IETD-FMK (ab141382), by ICC/IF. Decrease in active caspase 3 expression correlates with increased concentration of Z-IETD-FMK, as described in literature.
    The cells were incubated at 37°C for 1 hour in media containing different concentrations of ab141382 (Z-IETD-FMK) in DMSO. After this incupation 10 µM of camptothecin (ab120115) was added to all samples and the cells were incubated for further 24 hours. The samples were then fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab13847 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DA

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (5)

Publishing research using ab141382? Please let us know so that we can cite the reference in this datasheet.

ab141382 has been referenced in 5 publications.

  • Yang R  et al. SARS-CoV-2 Accessory Protein ORF7b Mediates Tumor Necrosis Factor-a-Induced Apoptosis in Cells. Front Microbiol 12:654709 (2021). PubMed: 34484133
  • Wang J  et al. Fundc1-dependent mitophagy is obligatory to ischemic preconditioning-conferred renoprotection in ischemic AKI via suppression of Drp1-mediated mitochondrial fission. Redox Biol 30:101415 (2020). PubMed: 31901590
  • Yang H  et al. Qingjie Fuzheng granules inhibit colorectal cancer cell growth by the PI3K/AKT and ERK pathways. World J Gastrointest Oncol 11:377-392 (2019). PubMed: 31139308
  • Liu G  et al. Beclin-1-mediated Autophagy Protects Against Cadmium-activated Apoptosis via the Fas/FasL Pathway in Primary Rat Proximal Tubular Cell Culture. Sci Rep 7:977 (2017). PubMed: 28428545
  • Zhao Y  et al. Berbamine inhibited the growth of prostate cancer cells in vivo and in vitro via triggering intrinsic pathway of apoptosis. Prostate Cancer Prostatic Dis 19:358-366 (2016). PubMed: 27431500

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