Z-Phe-Phe-FMK, Cathepsin B and L inhibitor (ab141386)
Key features and details
- Irreversible cathepsin B and L inhibitor. Cell-permeable.
- CAS Number: 108005-94-3
- Purity: > 95%
Supplied at 10 mM in DMSO.
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
Z-Phe-Phe-FMK, Cathepsin B and L inhibitor -
Description
Irreversible cathepsin B and L inhibitor. Cell-permeable. -
Purity
> 95% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called 1126 Cathepsin B&L Inhibitor Z-Phe-Phe-FMK. 1126-20C is the same size as the 20 µl size of ab141386.
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CAS Number
108005-94-3 -
Chemical structure
Properties
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Molecular weight
462.50 -
Molecular formula
C27H27FN2O4 -
Sequence
FF (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK) -
PubChem identifier
16760359 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Supplied at 10 mM in DMSO.
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C(C=C1)CC(C(=O)CF)NC(=O)C(CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3 -
Source
Synthetic
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Research areas
Associated products
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Related Products
Images
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Chemical Structure - Z-Phe-Phe-FMK, Cathepsin B and L inhibitor (ab141386)2D chemical structure image of ab141386, Z-Phe-Phe-FMK, Cathepsin B and L inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab141386 has been referenced in 2 publications.
- Berning L et al. Prodigiosin Sensitizes Sensitive and Resistant Urothelial Carcinoma Cells to Cisplatin Treatment. Molecules 26:N/A (2021). PubMed: 33673611
- Frew J et al. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Mol Neurodegener 15:21 (2020). PubMed: 32178712