Anti-ALDH3A1 antibody (ab76976)
Key features and details
- Rabbit polyclonal to ALDH3A1
- Suitable for: WB, ICC/IF, IHC-P
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-ALDH3A1 antibody
See all ALDH3A1 primary antibodies -
Description
Rabbit polyclonal to ALDH3A1 -
Host species
Rabbit -
Specificity
This antibody is predicted to have no cross reactivity to ALDH3A2. -
Tested applications
Suitable for: WB, ICC/IF, IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Synthetic peptide (Human): a 13 amino acid peptide from near the C terminus of human ALDH3A1. (NP_000682).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab76976 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 50 kDa.
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| ICC/IF |
Use at an assay dependent concentration.
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| IHC-P |
Use at an assay dependent concentration.
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| Notes |
|---|
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 50 kDa. |
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ICC/IF
Use at an assay dependent concentration. |
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IHC-P
Use at an assay dependent concentration. |
Target
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Function
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes. -
Tissue specificity
High levels in stomach, esophagus and lung; low level in the liver and kidney. -
Sequence similarities
Belongs to the aldehyde dehydrogenase family. -
Cellular localization
Cytoplasm. - Information by UniProt
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Database links
- Entrez Gene: 218 Human
- Entrez Gene: 11670 Mouse
- Entrez Gene: 25375 Rat
- Omim: 100660 Human
- SwissProt: P30838 Human
- SwissProt: P47739 Mouse
- SwissProt: P11883 Rat
- Unigene: 531682 Human
see all -
Alternative names
- Acetaldehyde dehydrogenase 3 antibody
- AHD 4 antibody
- AHD C antibody
see all
Images
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Western blot - Anti-ALDH3A1 antibody (ab76976)Lane 1 : Anti-ALDH3A1 antibody (ab76976) at 1 µg/ml
Lane 2 : Anti-ALDH3A1 antibody (ab76976) at 2 µg/ml
All lanes : human stomach lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 50 kDa
Observed band size: 50 kDa
Datasheets and documents
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SDS download
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Datasheet download
References (25)
ab76976 has been referenced in 25 publications.
- Nishtala K et al. Quantitative Proteomics Reveals Molecular Network Driving Stromal Cell Differentiation: Implications for Corneal Wound Healing. Int J Mol Sci 23:N/A (2022). PubMed: 35269714
- Fernández-Pérez J et al. The effect of prior long-term recellularization with keratocytes of decellularized porcine corneas implanted in a rabbit anterior lamellar keratoplasty model. PLoS One 16:e0245406 (2021). PubMed: 34061862
- Hull SM et al. 3D Bioprinting using UNIversal Orthogonal Network (UNION) Bioinks. Adv Funct Mater 31:N/A (2021). PubMed: 33613150
- Lee JS et al. Overall survival of pancreatic ductal adenocarcinoma is doubled by Aldh7a1 deletion in the KPC mouse. Theranostics 11:3472-3488 (2021). PubMed: 33537098
- Ryan SL et al. Identification of Proteins Deregulated by Platinum-Based Chemotherapy as Novel Biomarkers and Therapeutic Targets in Non-Small Cell Lung Cancer. Front Oncol 11:615967 (2021). PubMed: 33777753