Recombinant Alexa Fluor® 568 Anti-Lamin B2 antibody [EPR9701(B)] (ab312578)
![Alexa Fluor® 568 Anti-Lamin B2 antibody [EPR9701(B)] (ab312578)](https://www.abcam.com/ps/products/312/ab312578/Images/ab312578-1-MTOConjugatedRecombinantAntibodyBenefits.jpg "Alexa Fluor® 568 Anti-Lamin B2 antibody [EPR9701(B)] (ab312578)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Alexa Fluor® 568 Rabbit monoclonal [EPR9701(B)] to Lamin B2
- Suitable for: Target binding affinity, Antibody labelling
- Conjugation: Alexa Fluor® 568. Ex: 578nm, Em: 603nm
Related conjugates and formulations
Overview
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Product name
Alexa Fluor® 568 Anti-Lamin B2 antibody [EPR9701(B)]
See all Lamin B2 primary antibodies -
Description
Alexa Fluor® 568 Rabbit monoclonal [EPR9701(B)] to Lamin B2 -
Host species
Rabbit -
Conjugation
Alexa Fluor® 568. Ex: 578nm, Em: 603nm -
Tested applications
Suitable for: Target binding affinity, Antibody labellingmore details -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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General notes
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for Abtrial: learn more here.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. Store In the Dark. -
Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 30% Glycerol (glycerin, glycerine), 1% BSA, 68% PBS -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
EPR9701(B) -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
- Anti-Lamin B2 antibody [EPR9701(B)] (ab151735)
- Anti-Lamin B2 antibody [EPR9701(B)] - BSA and Azide free (ab240124)
- PE Anti-Lamin B2 antibody [EPR9701(B)] (ab303113)
- APC Anti-Lamin B2 antibody [EPR9701(B)] (ab303114)
- HRP Anti-Lamin B2 antibody [EPR9701(B)] (ab303115)
- AP Anti-Lamin B2 antibody [EPR9701(B)] (ab308838)
- Alexa Fluor® 594 Anti-Lamin B2 antibody [EPR9701(B)] (ab310568)
- Alexa Fluor® 555 Anti-Lamin B2 antibody [EPR9701(B)] (ab312097)
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab312578 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Target binding affinity |
Use at an assay dependent concentration.
|
|
| Antibody labelling |
Use at an assay dependent concentration.
|
| Notes |
|---|
|
Target binding affinity
Use at an assay dependent concentration. |
|
Antibody labelling
Use at an assay dependent concentration. |
Target
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Function
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. -
Involvement in disease
Defects in LMNB2 are a cause of partial acquired lipodystrophy (APLD) [MIM:608709]. A rare childhood disease characterized by loss of subcutaneous fat from the face and trunk. Fat deposition on the pelvic girdle and lower limbs is normal or excessive. Most frequently, onset between 5 and 15 years of age. Most affected subjects are females and some show no other abnormality, but many develop glomerulonephritis, diabetes mellitus, hyperlipidemia, and complement deficiency. Mental retardation in some cases. APLD is a sporadic disorder of unknown etiology. -
Sequence similarities
Belongs to the intermediate filament family. -
Post-translational
modificationsB-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. -
Cellular localization
Nucleus inner membrane. - Information by UniProt
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Alternative names
- LAMB 2 antibody
- LAMB2 antibody
- Lamin-B2 antibody
see all
Images
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Alexa Fluor® 568 Anti-Lamin B2 antibody [EPR9701(B)] (ab312578)
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab312578 has not yet been referenced specifically in any publications.