Recombinant AP Anti-CD276 antibody [SP265] - C-terminal (ab308973)
![AP Rabbit monoclonal [SP265] to CD276 - C-terminal (ab308973)](https://www.abcam.com/ps/products/308/ab308973/Images/ab308973-1-mto-conjugates-benefits-of-recombinant-antibodies.jpg "AP Rabbit monoclonal [SP265] to CD276 - C-terminal (ab308973)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Alkaline Phosphatase Rabbit monoclonal [SP265] to CD276 - C-terminal
- Suitable for: Target binding affinity, Antibody labelling
- Conjugation: Alkaline Phosphatase
Related conjugates and formulations
Overview
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Product name
AP Anti-CD276 antibody [SP265] - C-terminal
See all CD276 primary antibodies -
Description
Alkaline Phosphatase Rabbit monoclonal [SP265] to CD276 - C-terminal -
Host species
Rabbit -
Conjugation
Alkaline Phosphatase -
Tested applications
Suitable for: Target binding affinity, Antibody labellingmore details -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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General notes
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for Abtrial: learn more here.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. Store In the Dark. -
Storage buffer
pH: 7.40
Preservative: 0.1% Proclin 300 Solution
Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA, 0.016% Magnesium chloride, 0.001% Zinc chloride -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
SP265 -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
- PE Anti-CD276 antibody [SP265] (C-terminal) (ab305811)
- APC Anti-CD276 antibody [SP265] (C-terminal) (ab305812)
- HRP Anti-CD276 antibody [SP265] (C-terminal) (ab305813)
- Alexa Fluor® 488 Anti-CD276 antibody [SP265] - C-terminal (ab309918)
- Alexa Fluor® 647 Anti-CD276 antibody [SP265] - C-terminal (ab310286)
- Alexa Fluor® 594 Anti-CD276 antibody [SP265] - C-terminal (ab310747)
- Alexa Fluor® 555 Anti-CD276 antibody [SP265] - C-terminal (ab312274)
- Alexa Fluor® 568 Anti-CD276 antibody [SP265] - C-terminal (ab312767)
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab308973 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Target binding affinity |
Use at an assay dependent concentration.
|
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| Antibody labelling |
Use at an assay dependent concentration.
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| Notes |
|---|
|
Target binding affinity
Use at an assay dependent concentration. |
|
Antibody labelling
Use at an assay dependent concentration. |
Target
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Function
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. -
Tissue specificity
Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta. -
Sequence similarities
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 2 Ig-like V-type (immunoglobulin-like) domains. -
Cellular localization
Membrane. - Information by UniProt
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Alternative names
- 4Ig B7 H3 antibody
- 4Ig-B7-H3 antibody
- AU016588 antibody
see all
Images
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AP Rabbit monoclonal [SP265] to CD276 - C-terminal (ab308973)
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab308973 has not yet been referenced specifically in any publications.