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RecombinantRabMAb

Recombinant Anti-Cannabinoid Receptor I (phospho S316) antibody [EPR2223(N)] - BSA and Azide free (ab243927)

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  • Certificate of Compliance
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Anti-Cannabinoid Receptor I (phospho S316) antibody [EPR2223(N)] - BSA and Azide free (ab243927)

    Key features and details

    • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
    • Rabbit monoclonal [EPR2223(N)] to Cannabinoid Receptor I (phospho S316) - BSA and Azide free
    • Suitable for: WB
    • Reacts with: Human

    Conjugates logo Related conjugates and formulations

    Unconjugated

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    View more associated products

    Overview

    • Product name

      Anti-Cannabinoid Receptor I (phospho S316) antibody [EPR2223(N)] - BSA and Azide free
      See all Cannabinoid Receptor I primary antibodies
    • Description

      Rabbit monoclonal [EPR2223(N)] to Cannabinoid Receptor I (phospho S316) - BSA and Azide free
    • Host species

      Rabbit
    • Tested applications

      Suitable for: WBmore details
      Unsuitable for: Flow Cyt (Intra)
    • Species reactivity

      Reacts with: Human
    • Immunogen

      Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

    • Positive control

      • WB: Human fetal brain lysate.
    • General notes

      ab243927 is the carrier-free version of ab186428.

      Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. The carrier-free buffer and high concentration allow for increased conjugation efficiency.

      This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

      Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

      This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.

      This product is a recombinant monoclonal antibody, which offers several advantages including:

      • - High batch-to-batch consistency and reproducibility
      • - Improved sensitivity and specificity
      • - Long-term security of supply
      • - Animal-free production
      For more information see here.

      Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C. Do Not Freeze.
    • Storage buffer

      pH: 7.2
      Constituent: PBS
    • Carrier free

      Yes
    • Concentration information loading...
    • Purity

      Protein A purified
    • Clonality

      Monoclonal
    • Clone number

      EPR2223(N)
    • Isotype

      IgG
    • Research areas

      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • GPCR
      • Cannabinoid Receptor
      • Cardiovascular
      • Lipids / Lipoproteins
      • Lipid Metabolism
      • Cholesterol Metabolism
      • Cardiovascular
      • Atherosclerosis
      • Lipoprotein metabolism
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Lipid and lipoprotein metabolism
      • Cholesterol Metabolism
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Lipid and lipoprotein metabolism
      • Lipoprotein metabolism
      • Metabolism
      • Types of disease
      • Heart disease
      • Neuroscience
      • Processes

    Associated products

    • Alternative Versions

      • Anti-Cannabinoid Receptor I (phospho S316) antibody [EPR2223(N)] (ab186428)
    • Conjugation kits

      • PE / R-Phycoerythrin Conjugation Kit - Lightning-Link® (ab102918)
      • APC Conjugation Kit - Lightning-Link® (ab201807)
    • Isotype control

      • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)
    • Recombinant Protein

      • Recombinant Human Cannabinoid Receptor I protein (ab158150)
    • Related Products

      • Recombinant Human Cannabinoid Receptor I protein (ab158150)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab243927 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB
    Use at an assay dependent concentration. Detects a band of approximately 46, 53 kDa (predicted molecular weight: 53 kDa).
    Notes
    WB
    Use at an assay dependent concentration. Detects a band of approximately 46, 53 kDa (predicted molecular weight: 53 kDa).
    Application notes
    Is unsuitable for Flow Cyt (Intra).

    Target

    • Function

      Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
    • Tissue specificity

      Widely expressed.
    • Sequence similarities

      Belongs to the G-protein coupled receptor 1 family.
    • Cellular localization

      Cell membrane.
    • Target information above from: UniProt accession P21554 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 1268 Human
      • Omim: 114610 Human
      • SwissProt: P21554 Human
      • Unigene: 709067 Human
      • Unigene: 75110 Human
      • Alternative names

        • CANN6 antibody
        • Cannabinoid receptor 1 antibody
        • CB-R antibody
        • CB1 antibody
        • CB1A antibody
        • CB1K5 antibody
        • CB1R antibody
        • Central cannabinoid receptor antibody
        • CNR antibody
        • CNR1 antibody
        • CNR1_HUMAN antibody
        • OTTHUMP00000016838 antibody
        • OTTHUMP00000214579 antibody
        see all

      Images

      • Anti-Cannabinoid Receptor I (phospho S316) antibody [EPR2223(N)] - BSA and Azide free (ab243927)
        Anti-Cannabinoid Receptor I (phospho S316) antibody [EPR2223(N)] - BSA and Azide free (ab243927)

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet download

        Download

      Certificate of Compliance

      To download a Certificate of Compliance, please enter your Lot number below:

      References (0)

      Publishing research using ab243927? Please let us know so that we can cite the reference in this datasheet.

      ab243927 has not yet been referenced specifically in any publications.

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