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Anti-CYP11A1 antibody (ab223700)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP11A1 antibody (ab223700)

    Key features and details

    • Rabbit polyclonal to CYP11A1
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-CYP11A1 antibody
      See all CYP11A1 primary antibodies

    • Description

      Rabbit polyclonal to CYP11A1

    • Host species

      Rabbit

    • Tested applications

      Suitable for: IHC-Pmore details

    • Species reactivity

      Reacts with: Human
      Predicted to work with: Cynomolgus monkey

    • Immunogen

      Recombinant fragment corresponding to Human CYP11A1 aa 1-150.
      Database link: P05108

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • Positive control

      • IHC-P: Human adrenal gland tissue.

    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab223700 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P
    1/1000 - 1/2500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
    Notes
    IHC-P
    1/1000 - 1/2500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    Target

    • Function

      Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.

    • Pathway

      Lipid metabolism; C21-steroid hormone metabolism.

    • Involvement in disease

      Defects in CYP11A1 are a cause of congenital adrenal insufficiency (CAI).
      Defects in CYP11A1 are a cause of congenital lipoid adrenal hyperplasia (CLAH) [MIM:201710]; also known as lipoid CAH. CLAH is the most severe form of adrenal hyperplasia. This autosomal recessive and potentially lethal condition includes the onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. CLAH is a rare disease, except in Japan and Korea where it accounts for a significant percentage of cases of congenital adrenal hyperplasia.

    • Sequence similarities

      Belongs to the cytochrome P450 family.

    • Cellular localization

      Mitochondrion membrane.
    • Information by UniProt

    • Database links

      • Alternative names

        • Cholesterol 20 22 desmolase antibody
        • Cholesterol desmolase antibody
        • Cholesterol monooxygenase (side chain cleaving) antibody
        • Cholesterol side chain cleavage enzyme antibody
        • Cholesterol side chain cleavage enzyme mitochondrial antibody
        • Cholesterol side-chain cleavage enzyme antibody
        • CP11A_HUMAN antibody
        • CYP11A antibody
        • CYP11A1 antibody
        • CYPXIA1 antibody
        • Cytochrome P450 11A1 antibody
        • Cytochrome P450 11A1 mitochondrial antibody
        • Cytochrome P450 family 11 subfamily A polypeptide 1 antibody
        • Cytochrome P450 subfamily XIA antibody
        • Cytochrome P450(scc) antibody
        • Cytochrome P450C11A1 antibody
        • mitochondrial antibody
        • P450SCC antibody
        • Steroid 20 22 lyase antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP11A1 antibody (ab223700)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP11A1 antibody (ab223700)

        Paraffin-embedded human adrenal gland tissue stained for CYP11A1 using ab223700 at 1/1000 dilution in immunohistochemical analysis.

      References (0)

      Publishing research using ab223700? Please let us know so that we can cite the reference in this datasheet.

      ab223700 has not yet been referenced specifically in any publications.

      Customer reviews and Q&As

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