Anti-Elafin/ESI antibody [TRAB2F] (ab81681)
Key features and details
- Mouse monoclonal [TRAB2F] to Elafin/ESI
- Suitable for: ELISA, IHC-P, WB
- Reacts with: Human
- Isotype: IgG2b
Overview
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Product name
Anti-Elafin/ESI antibody [TRAB2F]
See all Elafin/ESI primary antibodies -
Description
Mouse monoclonal [TRAB2F] to Elafin/ESI -
Host species
Mouse -
Tested applications
Suitable for: ELISA, IHC-P, WBmore details
Unsuitable for: IHC-Fr -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Elafin/ESI (C terminal) conjugated to keyhole limpet haemocyanin.
Sequence:AQEPVKGPVSTKPGSC
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituents: 1% BSA, PBS -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
TRAB2F -
Isotype
IgG2b -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab81681 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| IHC-P |
Use at an assay dependent concentration.
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| WB |
Use at an assay dependent concentration. Predicted molecular weight: 12 kDa.
Use under reducing conditions. |
| Notes |
|---|
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ELISA
Use at an assay dependent concentration. |
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IHC-P
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. Predicted molecular weight: 12 kDa. Use under reducing conditions. |
Target
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Function
Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. -
Sequence similarities
Contains 1 WAP domain. -
Domain
Consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase inhibitor domain. The transglutaminase substrate domain serves as an anchor to localize elafin covalently to specific sites on extracellular matrix proteins. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 5266 Human
- Omim: 182257 Human
- SwissProt: P19957 Human
- Unigene: 112341 Human
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Alternative names
- Cementoin antibody
- ELAF_HUMAN antibody
- Elafin antibody
see all
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab81681 has been referenced in 3 publications.
- Zakizadeh F et al. Upregulation of elafin expression in the fallopian tube of ectopic tubal pregnancies compared to the normal tubes. J Reprod Immunol 141:103136 (2020). PubMed: 32485443
- Curciarello R et al. Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies. J Inflamm Res 13:233-243 (2020). PubMed: 32547155
- Desmet E et al. Towards the development of a RNAi-based topical treatment for psoriasis: Proof-of-concept in a 3D psoriasis skin model. Exp Dermatol 27:463-469 (2018). PubMed: 28833576