Anti-HMGCR (phospho S872) antibody (ab215437)
Key features and details
- Rabbit polyclonal to HMGCR (phospho S872)
- Suitable for: IHC-P, ELISA
- Reacts with: Mouse, Rat
- Isotype: IgG
Overview
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Product name
Anti-HMGCR (phospho S872) antibody
See all HMGCR primary antibodies -
Description
Rabbit polyclonal to HMGCR (phospho S872) -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, ELISAmore details -
Species reactivity
Reacts with: Mouse, Rat
Predicted to work with: Human
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Immunogen
Synthetic peptide within Human HMGCR aa 840-888 (C terminal) (phospho S871) conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
Database link: P04035 -
Positive control
- IHC-P: Rat liver tissue; Mouse brain and intestine tissues.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.2
Preservative: 0.09% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA
Aqueous buffered solution -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab215437 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P |
1/100 - 1/500.
|
|
| ELISA |
1/500 - 1/1000.
|
| Notes |
|---|
|
IHC-P
1/100 - 1/500. |
|
ELISA
1/500 - 1/1000. |
Target
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Function
This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis. -
Pathway
Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3. -
Sequence similarities
Belongs to the HMG-CoA reductase family. -
Cellular localization
Endoplasmic reticulum membrane. Peroxisome membrane. - Information by UniProt
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Database links
- Entrez Gene: 3156 Human
- Entrez Gene: 15357 Mouse
- Entrez Gene: 25675 Rat
- Omim: 142910 Human
- SwissProt: P04035 Human
- SwissProt: Q01237 Mouse
- SwissProt: P51639 Rat
- Unigene: 628096 Human
see all -
Alternative names
- 3 hydroxy 3 methylglutaryl CoA reductase antibody
- 3 hydroxy 3 methylglutaryl Coenzyme A reductase antibody
- 3 hydroxymethylglutaryl CoA reductase antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HMGCR (phospho S872) antibody (ab215437)
Formalin-fixed, paraffin-embedded mouse intestine tissue stained for HMGCR using ab215437 at 1/200 dilution in immunohistochemical analysis. Detection: DAB staining.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HMGCR (phospho S872) antibody (ab215437)Formalin-fixed, paraffin-embedded mouse brain tissue stained for HMGCR using ab215437 at 1/200 dilution in immunohistochemical analysis. Detection: DAB staining.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HMGCR (phospho S872) antibody (ab215437)Formalin-fixed, paraffin-embedded rat liver tissue stained for HMGCR using ab215437 at 1/200 dilution in immunohistochemical analysis. Detection: DAB staining.
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ELISA - Anti-HMGCR (phospho S872) antibody (ab215437)ELISA was performed using a serial dilution of ab215437 in antigen-coated wells. The antigen used was a peptide containing the phosphosite of interest. The plot shows the absorbance against the antibody dilution for phosphopeptide and non phosphopeptide antigen.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab215437 has not yet been referenced specifically in any publications.