Recombinant HRP Anti-DYNLL1 / PIN antibody [EP1660Y] (ab305984)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- HRP Rabbit monoclonal [EP1660Y] to DYNLL1/PIN
- Suitable for: Target binding affinity, Antibody labelling
- Conjugation: HRP
Related conjugates and formulations
Overview
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Product name
HRP Anti-DYNLL1 / PIN antibody [EP1660Y]
See all DYNLL1/PIN primary antibodies -
Description
HRP Rabbit monoclonal [EP1660Y] to DYNLL1/PIN -
Host species
Rabbit -
Conjugation
HRP -
Tested applications
Suitable for: Target binding affinity, Antibody labellingmore details -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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Epitope
The epitope for this antibody is on the N-terminus, AA2-14. -
General notes
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for Abtrial: learn more here.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. Store In the Dark. -
Storage buffer
pH: 7.40
Preservative: 0.1% Proclin 300 Solution
Constituents: 30% Glycerol (glycerin, glycerine), 1% BSA, 68% PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
EP1660Y -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
- Anti-DYNLL1/PIN antibody [EP1660Y] - BSA and Azide free (ab232343)
- AP Anti-DYNLL1 / PIN antibody [EP1660Y] (ab308814)
- Alexa Fluor® 647 Anti-DYNLL1 / PIN antibody [EP1660Y] (ab310128)
- Alexa Fluor® 594 Anti-DYNLL1 / PIN antibody [EP1660Y] (ab310545)
- Alexa Fluor® 555 Anti-DYNLL1 / PIN antibody [EP1660Y] (ab312075)
- Alexa Fluor® 568 Anti-DYNLL1 / PIN antibody [EP1660Y] (ab312552)
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab305984 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
Target binding affinity |
Use at an assay dependent concentration.
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Antibody labelling |
Use at an assay dependent concentration.
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Notes |
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Target binding affinity
Use at an assay dependent concentration. |
Antibody labelling
Use at an assay dependent concentration. |
Target
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Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.
Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.
Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity. -
Tissue specificity
Ubiquitous. -
Sequence similarities
Belongs to the dynein light chain family. -
Post-translational
modificationsPhosphorylation at Ser-88 appears to control the dimer-monomer transition. According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro. -
Cellular localization
Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Upon induction of apoptosis translocates together with BCL2L11 to mitochondria. - Information by UniProt
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Alternative names
- 8 kDa dynein light chain antibody
- 8kDLC antibody
- Cytoplasmic dynein light polypeptide antibody
see all
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab305984 has not yet been referenced specifically in any publications.