Anti-IL-21 antibody (ab154767)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-21 antibody (ab154767)
  • Western blot - Anti-IL-21 antibody (ab154767)

Key features and details

  • Rabbit polyclonal to IL-21
  • Suitable for: WB, IHC-P
  • Reacts with: Human
  • Isotype: IgG

Overview

  • Product name

    Anti-IL-21 antibody
    See all IL-21 primary antibodies

  • Description

    Rabbit polyclonal to IL-21

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WB, IHC-Pmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Monkey

  • Immunogen

    Recombinant fragment corresponding to Human IL-21 aa 1-155.
    Database link: Q9HBE4

  • Positive control

    • HL60 whole cell lysate; Human colon carcinoma tissue

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab154767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
1/500 - 1/3000. Predicted molecular weight: 17 kDa.
IHC-P
1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Notes
WB
1/500 - 1/3000. Predicted molecular weight: 17 kDa.
IHC-P
1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

  • Tissue specificity

    Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.

  • Sequence similarities

    Belongs to the IL-15/IL-21 family.

  • Cellular localization

    Secreted.
  • Information by UniProt

  • Database links

    • Alternative names

      • CVID11 antibody
      • IL 21 antibody
      • IL-21 antibody
      • Il21 antibody
      • IL21_HUMAN antibody
      • Interleukin 21 antibody
      • Interleukin-21 antibody
      • interleukin-21 isoform antibody
      • Interleukin21 antibody
      • OTTHUMP00000164088 antibody
      • Za11 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-21 antibody (ab154767)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-21 antibody (ab154767)
      Immunohistochemical analysis of paraffin embedded Human colon carcinoma tissue labeling IL21 with ab154767 at 1/500 dilution.
    • Western blot - Anti-IL-21 antibody (ab154767)
      Western blot - Anti-IL-21 antibody (ab154767)
      Anti-IL-21 antibody (ab154767) at 1/1000 dilution + HL60 whole cell lysate at 30 µg

      Predicted band size: 17 kDa



      12% SDS PAGE

    References (1)

    Publishing research using ab154767? Please let us know so that we can cite the reference in this datasheet.

    ab154767 has been referenced in 1 publication.

    • Hu J  et al. [Immunoexpression and clinical significance of interleukin-21 and receptor activator of nuclear factor ?B ligand in human periapical granulomas and radicular cysts]. Hua Xi Kou Qiang Yi Xue Za Zhi 33:244-8 (2015). PubMed: 26281250

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