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  1. Link

    products/primary-antibodies/il-21-antibody-ab154767.pdf

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Immunology Innate Immunity Cytokines Interleukins
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Anti-IL-21 antibody (ab154767)

  • Datasheet
  • SDS
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-21 antibody (ab154767)
  • Western blot - Anti-IL-21 antibody (ab154767)

Key features and details

  • Rabbit polyclonal to IL-21
  • Suitable for: WB, IHC-P
  • Reacts with: Human
  • Isotype: IgG

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Anti-IL-21R antibody (ab5980)

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Overview

  • Product name

    Anti-IL-21 antibody
    See all IL-21 primary antibodies
  • Description

    Rabbit polyclonal to IL-21
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Monkey
  • Immunogen

    Recombinant fragment corresponding to Human IL-21 aa 1-155.
    Database link: Q9HBE4

  • Positive control

    • HL60 whole cell lysate; Human colon carcinoma tissue
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine)
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Immunology
    • Innate Immunity
    • Cytokines
    • Interleukins
    • Cancer
    • Tumor immunology
    • Cytokines
    • Interleukins
    • Neuroscience
    • Processes

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • HL-60 whole cell lysate (ab7914)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab154767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
1/500 - 1/3000. Predicted molecular weight: 17 kDa.
IHC-P
1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Notes
WB
1/500 - 1/3000. Predicted molecular weight: 17 kDa.
IHC-P
1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
  • Tissue specificity

    Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.
  • Sequence similarities

    Belongs to the IL-15/IL-21 family.
  • Cellular localization

    Secreted.
  • Target information above from: UniProt accession Q9HBE4 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 59067 Human
    • Omim: 605384 Human
    • SwissProt: Q9HBE4 Human
    • Unigene: 567559 Human
    • Alternative names

      • CVID11 antibody
      • IL 21 antibody
      • IL-21 antibody
      • Il21 antibody
      • IL21_HUMAN antibody
      • Interleukin 21 antibody
      • Interleukin-21 antibody
      • interleukin-21 isoform antibody
      • Interleukin21 antibody
      • OTTHUMP00000164088 antibody
      • Za11 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-21 antibody (ab154767)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-21 antibody (ab154767)
      Immunohistochemical analysis of paraffin embedded Human colon carcinoma tissue labeling IL21 with ab154767 at 1/500 dilution.
    • Western blot - Anti-IL-21 antibody (ab154767)
      Western blot - Anti-IL-21 antibody (ab154767)
      Anti-IL-21 antibody (ab154767) at 1/1000 dilution + HL60 whole cell lysate at 30 µg

      Predicted band size: 17 kDa



      12% SDS PAGE

    Protocols

    • Western blot protocols
    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (1)

    Publishing research using ab154767? Please let us know so that we can cite the reference in this datasheet.

    ab154767 has been referenced in 1 publication.

    • Hu J  et al. [Immunoexpression and clinical significance of interleukin-21 and receptor activator of nuclear factor ?B ligand in human periapical granulomas and radicular cysts]. Hua Xi Kou Qiang Yi Xue Za Zhi 33:244-8 (2015). PubMed: 26281250

    Customer reviews and Q&As

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