Anti-Integrin alpha V antibody (ab117611)
Key features and details
- Rabbit polyclonal to Integrin alpha V
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-Integrin alpha V antibody
See all Integrin alpha V primary antibodies -
Description
Rabbit polyclonal to Integrin alpha V -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide conjugated to KLH corresponding to C terminal residues of Human Integrin alpha V (NP_002201.1).
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Positive control
- Human Placenta and Thyroid tissues; A549 cell extracts, treated with etoposide.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 0.88% Sodium chloride, 50% Glycerol (glycerin, glycerine)
PBS (without Mg2+, Ca2+) -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab117611 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB |
1/500 - 1/1000. Predicted molecular weight: 116 kDa.
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| IHC-P | (1) |
Use a concentration of 5 µg/ml.
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| Notes |
|---|
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WB
1/500 - 1/1000. Predicted molecular weight: 116 kDa. |
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IHC-P
Use a concentration of 5 µg/ml. |
Target
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Function
The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. -
Sequence similarities
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 3685 Human
- Omim: 193210 Human
- SwissProt: P06756 Human
- Unigene: 436873 Human
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Alternative names
- antigen identified by monoclonal antibody L230 antibody
- CD 51 antibody
- CD51 antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha V antibody (ab117611)ab117611, at 5 µg/ml, staining Integrin alpha V in Formalin-fixed, Paraffin-embedded Human Thyroid tissue by Immunohistochemistry.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha V antibody (ab117611)ab117611, at 5 µg/ml, staining Integrin alpha V in Formalin-fixed, Paraffin-embedded Human Placenta tissue by Immunohistochemistry. -
Western blot - Anti-Integrin alpha V antibody (ab117611)All lanes : Anti-Integrin alpha V antibody (ab117611) at 1/500 dilution
Lane 1 : A549 cell extracts, treated with etoposide 25uM 1hr
Lane 2 : A549 cell extracts, treated with etoposide 25uM 1h with synthetic peptide
Predicted band size: 116 kDa
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (4)
ab117611 has been referenced in 4 publications.
- Ji Q et al. Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation. Nat Commun 11:1211 (2020). PubMed: 32139701
- Spinelli C et al. Molecular subtypes and differentiation programmes of glioma stem cells as determinants of extracellular vesicle profiles and endothelial cell-stimulating activities. J Extracell Vesicles 7:1490144 (2018). PubMed: 30034643
- Vogt D et al. Premacular membranes in tissue culture. Graefes Arch Clin Exp Ophthalmol N/A:N/A (2018). PubMed: 29931427
- Hoshino A et al. Tumour exosome integrins determine organotropic metastasis. Nature 527:329-35 (2015). WB ; Human . PubMed: 26524530