Anti-KCNV2 antibody (ab214587)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KCNV2 antibody (ab214587)

    Key features and details

    • Rabbit polyclonal to KCNV2
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-KCNV2 antibody

    • Description

      Rabbit polyclonal to KCNV2

    • Host species

      Rabbit

    • Tested applications

      Suitable for: IHC-Pmore details

    • Species reactivity

      Reacts with: Human
      Predicted to work with: Mouse, Rat

    • Immunogen

      Synthetic peptide within Human KCNV2 aa 150-250 conjugated to keyhole limpet haemocyanin. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
      Database link: Q8TDN2

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • Positive control

      • Human colon carcinoma tissue.

    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab214587 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P
    1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
    Notes
    IHC-P
    1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    Target

    • Function

      Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.

    • Tissue specificity

      Detected in lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary and colon.

    • Involvement in disease

      Defects in KCNV2 are the cause of cone dystrophy retinal type 3B (RCD3B) [MIM:610356]; also called cone dystrophy with night blindness and supernormal rod responses KCNV2-related. RCD3B is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy.

    • Sequence similarities

      Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily.

    • Domain

      The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    • Cellular localization

      Cell membrane. Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.
    • Information by UniProt

    • Database links

      see all

    • Alternative names

      • KCNV2 antibody
      • KCNV2_HUMAN antibody
      • KV11.1 antibody
      • Kv8.2 antibody
      • MGC120515 antibody
      • Potassium channel subfamily V member 2 antibody
      • Potassium voltage-gated channel subfamily V member 2 antibody
      • RCD3B antibody
      • Voltage-gated potassium channel Kv8.2 antibody
      • Voltage-gated potassium channel subunit Kv8.2 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KCNV2 antibody (ab214587)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KCNV2 antibody (ab214587)

      Immunohistochemical analysis of paraformaldehyde-fixed, paraffin-embedded human colon carcinoma tissue labeling KCNV2 with ab214587 at 1/400 dilution, followed by secondary antibody detection and DAB staining.

      Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min.

    References (0)

    Publishing research using ab214587? Please let us know so that we can cite the reference in this datasheet.

    ab214587 has not yet been referenced specifically in any publications.

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