Anti-Osteocalcin antibody (ab93876)
Key features and details
- Rabbit polyclonal to Osteocalcin
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
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- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-Osteocalcin antibody
See all Osteocalcin primary antibodies -
Description
Rabbit polyclonal to Osteocalcin -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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Positive control
- IHC-P: Liver carcinoma tissue WB: Lung tissue lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading... -
Purity
Protein A purified -
Purification notes
Affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab93876 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB |
Use at an assay dependent concentration. Predicted molecular weight: 11 kDa.
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| IHC-P | (3) |
Use at an assay dependent concentration.
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| Notes |
|---|
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WB
Use at an assay dependent concentration. Predicted molecular weight: 11 kDa. |
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IHC-P
Use at an assay dependent concentration. |
Target
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Function
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. -
Sequence similarities
Belongs to the osteocalcin/matrix Gla protein family.
Contains 1 Gla (gamma-carboxy-glutamate) domain. -
Post-translational
modificationsGamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 632 Human
- Entrez Gene: 12096 Mouse
- Omim: 112260 Human
- SwissProt: P02818 Human
- SwissProt: P86546 Mouse
- Unigene: 654541 Human
- Unigene: 389459 Mouse
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Alternative names
- BGLAP antibody
- BGP antibody
- Bone gamma carboxyglutamate (gla) protein antibody
see all
Images
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Western blot - Anti-Osteocalcin antibody (ab93876)Anti-Osteocalcin antibody (ab93876) at 1/100 dilution + Mouse lung tissue lysate
Predicted band size: 11 kDaWestern blot analysis of mouse lung tissue lysate with anti-osteocalcin antibody.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Osteocalcin antibody (ab93876)Immunohistochemical staining of formalin-fixed paraffin-embedded liver carcinoma staining with anti-osteocalcin antibody at a dilution of 1/100.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (288)
ab93876 has been referenced in 288 publications.
- Wu C et al. Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling. Genes Dis 11:964-977 (2024). WB ; Mouse . PubMed: 37692479
- Sun B et al. Irisin reduces bone fracture by facilitating osteogenesis and antagonizing TGF-β/Smad signaling in a growing mouse model of osteogenesis imperfecta. J Orthop Translat 38:175-189 (2023). PubMed: 36439629
- Luo J et al. Cerium Oxide Nanoparticles Promote Osteoplastic Precursor Differentiation by Activating the Wnt Pathway. Biol Trace Elem Res 201:865-873 (2023). PubMed: 35230639
- Luzuriaga J et al. Osteogenic differentiation of human dental pulp stem cells in decellularised adipose tissue solid foams. Eur Cell Mater 43:112-129 (2022). PubMed: 35312032
- Song YQ et al. Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight. J Mol Med (Berl) 100:723-734 (2022). PubMed: 35314877