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Signal Transduction Protein Trafficking Chaperones Heat Shock Proteins
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RecombinantRabMAb

Recombinant PE Anti-STUB1 / CHIP antibody [EPR4447] (ab303131)

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  • SDS
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PE Anti-STUB1 / CHIP antibody [EPR4447] (ab303131)

    Key features and details

    • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
    • PE Rabbit monoclonal [EPR4447] to STUB1/CHIP
    • Suitable for: Target binding affinity, Antibody labelling
    • Conjugation: PE. Ex: 488nm, Em: 575nm

    Conjugates logo Related conjugates and formulations

    APC Carrier Free HRP Unconjugated

    Overview

    • Product name

      PE Anti-STUB1 / CHIP antibody [EPR4447]
      See all STUB1/CHIP primary antibodies
    • Description

      PE Rabbit monoclonal [EPR4447] to STUB1/CHIP
    • Host species

      Rabbit
    • Conjugation

      PE. Ex: 488nm, Em: 575nm
    • Tested applications

      Suitable for: Target binding affinity, Antibody labellingmore details
    • Immunogen

      Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

    • General notes

      This conjugated primary antibody is manufactured using Abcam's Lightning-Link® technology. It is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.

      For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for Abtrial: learn more here.

      This product is a recombinant monoclonal antibody, which offers several advantages including:

      • - High batch-to-batch consistency and reproducibility
      • - Improved sensitivity and specificity
      • - Long-term security of supply
      • - Animal-free production
      For more information see here.

      Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at +4°C. Store In the Dark.
    • Storage buffer

      pH: 7.40
      Preservative: 0.02% Sodium azide
      Constituents: 98% PBS, 1% BSA
    • Concentration information loading...
    • Purity

      Protein A purified
    • Clonality

      Monoclonal
    • Clone number

      EPR4447
    • Isotype

      IgG
    • Research areas

      • Signal Transduction
      • Protein Trafficking
      • Chaperones
      • Heat Shock Proteins
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • SMADs
      • Epigenetics and Nuclear Signaling
      • Cell cycle
      • Ubiquitin ligases
      • Epigenetics and Nuclear Signaling
      • Ubiquitin & Ubiquitin Like Modifiers
      • E3 Ubiquitin Ligases
      • Neuroscience
      • Processes

    Associated products

    • Alternative Versions

      • Anti-STUB1/CHIP antibody [EPR4447] - BSA and Azide free (ab238966)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab303131 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Target binding affinity
    Use at an assay dependent concentration.
    Antibody labelling
    Use at an assay dependent concentration.
    Notes
    Target binding affinity
    Use at an assay dependent concentration.
    Antibody labelling
    Use at an assay dependent concentration.

    Target

    • Function

      E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4.
    • Tissue specificity

      Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung.
    • Pathway

      Protein modification; protein ubiquitination.
    • Sequence similarities

      Contains 3 TPR repeats.
      Contains 1 U-box domain.
    • Domain

      The TPR domain is essential for ubiquitination mediated by UBE2D1.
    • Post-translational
      modifications

      Phosphorylated upon DNA damage, probably by ATM or ATR.
      Auto-ubiquitinated; mediated by UBE2D1 and UBE2D2.
    • Cellular localization

      Cytoplasm.
    • Target information above from: UniProt accession Q9UNE7 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Alternative names

      • Antigen NY CO 7 antibody
      • Antigen NY-CO-7 antibody
      • C terminus of Hsp70-interacting protein antibody
      • Carboxy terminus of Hsp70 interacting protein antibody
      • Carboxy terminus of Hsp70-interacting protein antibody
      • Carboxy terminus of Hsp70p interacting protein antibody
      • CHIP antibody
      • CHIP_HUMAN antibody
      • CLL associated antigen KW 8 antibody
      • CLL-associated antigen KW-8 antibody
      • E3 ubiquitin protein ligase CHIP antibody
      • E3 ubiquitin-protein ligase CHIP antibody
      • Heat shock protein A binding protein 2 (c terminal) antibody
      • HSPABP2 antibody
      • NY CO 7 antibody
      • PP1131 antibody
      • SDCCAG7 antibody
      • Serologically defined colon cancer antigen 7 antibody
      • STIP1 homology and U Box containing protein 1 antibody
      • STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase antibody
      • STIP1 homology and U box-containing protein 1 antibody
      • STUB 1 antibody
      • STUB1 antibody
      • UBOX 1 antibody
      • UBOX1 antibody
      see all

    Images

    • PE Anti-STUB1 / CHIP antibody [EPR4447] (ab303131)
      PE Anti-STUB1 / CHIP antibody [EPR4447] (ab303131)

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (0)

    Publishing research using ab303131? Please let us know so that we can cite the reference in this datasheet.

    ab303131 has not yet been referenced specifically in any publications.

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