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    products/primary-antibodies/pp2a-alpha--beta-antibody-ye351-ab32065.pdf

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RecombinantRabMAb

Recombinant Anti-PP2A alpha + beta antibody [YE351] (ab32065)

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  • SDS
Reviews (1)Q&A (1)References (4)

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Western blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
  • Western blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
  • Western blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
  • Western blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
  • Western blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
  • Immunoprecipitation - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
  • Dot Blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
  • Anti-PP2A alpha + beta antibody [YE351] (ab32065)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [YE351] to PP2A alpha + beta
  • Suitable for: IP, WB, IHC-P, Dot blot
  • Reacts with: Mouse, Rat, Human

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Carrier Free

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Overview

  • Product name

    Anti-PP2A alpha + beta antibody [YE351]
    See all PP2A alpha + beta primary antibodies
  • Description

    Rabbit monoclonal [YE351] to PP2A alpha + beta
  • Host species

    Rabbit
  • Specificity

    This antibody can bind both alpha and beta form of PP2A. Mouse samples have been successfully tested in WB, but IHC-P sections from various mouse tissues showed negative results.
  • Tested applications

    Suitable for: IP, WB, IHC-P, Dot blotmore details
    Unsuitable for: Flow Cyt or ICC/IF
  • Species reactivity

    Reacts with: Mouse, Rat, Human
    Predicted to work with: Cow, Pig
  • Immunogen

    Synthetic peptide within Human PP2A alpha + beta (N terminal). The exact sequence is proprietary.

  • Epitope

    ab32065 reacts with an epitope located in the N terminal region of PP2A alpha.
  • Positive control

    • WB: A431 cell lysate and NIH 3T3 cell lysate. Dot Blot: PP2A-alpha peptide and PP2A-beta peptide.
  • General notes

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.05% BSA
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Monoclonal
  • Clone number

    YE351
  • Isotype

    IgG
  • Research areas

    • Cell Biology
    • Cell Cycle
    • Kinases/Phosphatases
    • Phosphatases
    • Cell Biology
    • Cell Cycle
    • Kinases/Phosphatases
    • Other
    • Neuroscience
    • Neurotransmission
    • Intracellular Signaling
    • Phosphatases
    • Signal Transduction
    • Protein Phosphorylation
    • Ser / Thr Phosphatases
    • Stem Cells
    • Signaling Pathways
    • Wnt
    • Cytoplasmic
    • Epigenetics and Nuclear Signaling
    • Cell cycle
    • Kinases/Phosphatases
    • Other
    • Stem Cells
    • Signaling Pathways
    • TGF beta
    • Cytoplasmic
    • Cancer
    • Cell cycle
    • Kinases/phosphatases
    • Phosphatases
    • Cardiovascular
    • Heart
    • Contractility
    • Contractile Proteins
    • Troponin

Associated products

  • Alternative Versions

    • Anti-PP2A alpha + beta antibody [YE351] - BSA and Azide free (ab232450)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab32065 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP
1/80.
WB (1)
1/500. Predicted molecular weight: 36 kDa.
IHC-P
1/50 - 1/100. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Dot blot
Use at an assay dependent concentration.
Notes
IP
1/80.
WB
1/500. Predicted molecular weight: 36 kDa.
IHC-P
1/50 - 1/100. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Dot blot
Use at an assay dependent concentration.
Application notes
Is unsuitable for Flow Cyt or ICC/IF.

Target

  • Function

    PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at 'Ser-259'.
  • Sequence similarities

    Belongs to the PPP phosphatase family. PP-1 subfamily.
  • Post-translational
    modifications

    Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly, enhancing the affinity of the PP2A core enzyme for some, but not all, regulatory subunits. It varies during the cell cycle.
    Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
  • Cellular localization

    Cytoplasm. Nucleus. Chromosome > centromere. Cytoplasm > cytoskeleton > spindle pole. In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2.
  • Target information above from: UniProt accession P67775 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 5515 Human
    • Entrez Gene: 5516 Human
    • Entrez Gene: 19052 Mouse
    • Entrez Gene: 19053 Mouse
    • Entrez Gene: 397136 Pig
    • Entrez Gene: 397656 Pig
    • Entrez Gene: 24672 Rat
    • Entrez Gene: 24673 Rat
    • Omim: 176915 Human
    • Omim: 176916 Human
    • SwissProt: P67774 Cow
    • SwissProt: Q0P594 Cow
    • SwissProt: P62714 Human
    • SwissProt: P67775 Human
    • SwissProt: P62715 Mouse
    • SwissProt: P63330 Mouse
    • SwissProt: P62716 Rat
    • SwissProt: P63331 Rat
    • Unigene: 105818 Human
    • Unigene: 260288 Mouse
    • Unigene: 1271 Rat
    see all
  • Alternative names

    • PP2A A antibody
    • PP2A alpha antibody
    • PP2A B antibody
    • PP2A beta antibody
    • PP2A-alpha antibody
    • PP2A-beta antibody
    • PP2AA_HUMAN antibody
    • PP2Aalpha antibody
    • PP2AB_HUMAN antibody
    • PP2Abeta antibody
    • PP2Ac antibody
    • PP2CA antibody
    • PP2Calpha antibody
    • PP2CB antibody
    • PPP2CA antibody
    • PPP2CB antibody
    • Protein phosphatase 2 catalytic subunit alpha isoform antibody
    • Protein phosphatase 2 catalytic subunit beta isoform antibody
    • Protein phosphatase type 2A catalytic subunit antibody
    • Replication protein C antibody
    • RP C antibody
    • RP-C antibody
    • RPC antibody
    • Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform antibody
    • Serine/threonine protein phosphatase 2A catalytic subunit beta isoform antibody
    • Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform antibody
    see all

Images

  • Western blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    Western blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    All lanes : Anti-PP2A alpha + beta antibody [YE351] (ab32065) at 1/50000 dilution

    Lane 1 : A431 whole cell lysate
    Lane 2 : A549 whole cell lysate
    Lane 3 : Caco-2 whole cell lysate
    Lane 4 : T47D whole cell lysate
    Lane 5 : C2C12 whole cell lysate
    Lane 6 : HeLa whole cell lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    All lanes : Peroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

    Predicted band size: 36 kDa
    Observed band size: 36 kDa


    Exposure time: 15 seconds


    Blocking and dilution buffer: 5% NFDM/TBST.

  • Western blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    Western blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    All lanes : Anti-PP2A alpha + beta antibody [YE351] (ab32065) at 1/50000 dilution

    Lane 1 : Jurkat whole cell lysate
    Lane 2 : U-937 whole cell lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    All lanes : Peroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

    Predicted band size: 36 kDa
    Observed band size: 36 kDa


    Exposure time: 5 seconds


    Blocking and dilution buffer: 5% NFDM/TBST.

  • Western blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    Western blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    All lanes : Anti-PP2A alpha + beta antibody [YE351] (ab32065) at 1/100000 dilution

    Lane 1 : Human fetal heart tissue lysate
    Lane 2 : Human fetal kidney tissue lysate
    Lane 3 : Human fetal spleen tissue lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    All lanes : HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG at 1/1000 dilution

    Predicted band size: 36 kDa
    Observed band size: 36 kDa


    Exposure time: 30 seconds


    Blocking and dilution buffer: 5% NFDM/TBST.

  • Western blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    Western blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    Anti-PP2A alpha + beta antibody [YE351] (ab32065) at 1/100000 dilution + Human fetal brain tissue lysate at 10 µg

    Secondary
    HRP-conjugate anti-rabbit IgG, specific to the non-reduced form of IgG at 1/1000 dilution

    Predicted band size: 36 kDa
    Observed band size: 36 kDa


    Exposure time: 15 seconds


    Blocking and dilution buffer: 5% NFDM /TBST.

  • Western blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    Western blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    All lanes : Anti-PP2A alpha + beta antibody [YE351] (ab32065) at 1/100000 dilution

    Lane 1 : Mouse brain tissue lysate
    Lane 2 : Mouse heart tissue lysate
    Lane 3 : Mouse kidney tissue lysate
    Lane 4 : Mouse spleen tissue lysate
    Lane 5 : Rat brain tissue lysate
    Lane 6 : Rat heart tissue lysate
    Lane 7 : Rat kidney tissue lysate
    Lane 8 : Rat spleen tissue lysate
    Lane 9 : C6 whole cell lysate
    Lane 10 : Raw264.7 whole cell lysate
    Lane 11 : PC-12 whole cell lysate
    Lane 12 : NIH/3T3 whole cell lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    All lanes : Peroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

    Predicted band size: 36 kDa
    Observed band size: 36 kDa


    Exposure time: 1 second


    Blocking and dilution buffer: 5% NFDM /TBST.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PP2A alpha + beta antibody [YE351] (ab32065)

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human tonsil tissue labeling PP2A alpha + beta with ab32065 at a dilution of 1/100. Heat mediated antigen retrieval was performed using Tris/EDTA buffer pH 9. ab97051, a HRP-conjugated goat anti-rabbit IgG (H+L) was used as the secondary antibody (1/500). Negative control using PBS instead of primary antibody. Counterstained with hematoxylin.

    Cytoplasm and weak nucleus staining is visible in lymphocytes of human tonsil.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PP2A alpha + beta antibody [YE351] (ab32065)

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of mouse kidney tissue labelling PP2A alpha + beta with ab32065 at a dilution of 1/100. Heat mediated antigen retrieval was performed using Tris/EDTA buffer pH 9. ab97051, a HRP-conjugated goat anti-rabbit IgG (H+L) was used as the secondary antibody (1/500). Negative control using PBS instead of primary antibody. Counterstained with hematoxylin.

    Cytoplasm staining is visible in epithelial cells of mouse kidney

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PP2A alpha + beta antibody [YE351] (ab32065)

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat kidney tissue labelling PP2A alpha + beta with ab32065 at a dilution of 1/100. Heat mediated antigen retrieval was performed using Tris/EDTA buffer pH 9. ab97051, a HRP-conjugated goat anti-rabbit IgG (H+L) was used as the secondary antibody (1/500). Negative control using PBS instead of primary antibody. Counterstained with hematoxylin.

    Cytoplasm and weak nucleus staining is visible in epithelial cells of rat kidney.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PP2A alpha + beta antibody [YE351] (ab32065)

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of mouse heart tissue labelling PP2A alpha + beta with ab32065 at a dilution of 1/100. Heat mediated antigen retrieval was performed using Tris/EDTA buffer pH 9. ab97051, a HRP-conjugated goat anti-rabbit IgG (H+L) was used as the secondary antibody (1/500). Negative control using PBS instead of primary antibody. Counterstained with hematoxylin.

    Cytoplasm staining is visible in mouse heart.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PP2A alpha + beta antibody [YE351] (ab32065)

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat heart tissue labelling PP2A alpha + beta with ab32065 at a dilution of 1/100. Heat mediated antigen retrieval was performed using Tris/EDTA buffer pH 9. ab97051, a HRP-conjugated goat anti-rabbit IgG (H+L) was used as the secondary antibody (1/500). Negative control using PBS instead of primary antibody. Counterstained with hematoxylin.

    Cytoplasm and nucleus staining is visible on rat heart.

  • Immunoprecipitation - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    Immunoprecipitation - Anti-PP2A alpha + beta antibody [YE351] (ab32065)

    ab32065 at 1/80 immunoprecipitating PP2A alpha + beta in HeLa whole cell lysate.

    Lane 1 (input): HeLa whole cell lysate (10µg)

    Lane 2 (+): ab32065 + HeLa whole cell lysate.

    Lane 3 (-): Rabbit monoclonal IgG (ab172730) instead of ab32065 in HeLa (human cervix adenocarcinoma) whole cell lysate.

    For western blotting, ab32065 (1/500) ab131366 VeriBlot for IP Detection Reagent (HRP) was used for detection (1/10000).

    Blocking buffer and concentration: 5% NFDM/TBST.

    Diluting buffer and concentration: 5% NFDM /TBST.

    Observed band: 37kDa.

     

  • Dot Blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    Dot Blot - Anti-PP2A alpha + beta antibody [YE351] (ab32065)

    Dot blot analysis of PP2A-alpha peptide (Lane 1) and PP2A-beta peptide (Lane 2) labelling PP2A alpha+beta with ab32065 at a dilution of 1/1000. A HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the secondary antibody at a dilution of 1/1000.

    Blocking and dilution buffer: 5% NFDM/TBST.

    Exposure time: 3 minutes.

  • Anti-PP2A alpha + beta antibody [YE351] (ab32065)
    Anti-PP2A alpha + beta antibody [YE351] (ab32065)

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (4)

Publishing research using ab32065? Please let us know so that we can cite the reference in this datasheet.

ab32065 has been referenced in 4 publications.

  • Albadrani M  et al. Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21. Am J Physiol Gastrointest Liver Physiol 317:G408-G428 (2019). PubMed: 31393787
  • Tang S  et al. Hydrogen peroxide redistributes the localization of protein phosphatase methylesterase 1. Life Sci 213:166-173 (2018). PubMed: 30340029
  • Park HJ  et al. Protein Phosphatase 2A and Its Methylation Modulating Enzymes LCMT-1 and PME-1 Are Dysregulated in Tauopathies of Progressive Supranuclear Palsy and Alzheimer Disease. J Neuropathol Exp Neurol 77:139-148 (2018). PubMed: 29281045
  • Langlois B  et al. LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways. PLoS One 5:e11584 (2010). WB . PubMed: 20644732

Customer reviews and Q&As

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1-2 of 2 Abreviews or Q&A

Western blot abreview for Anti-PP2A alpha + beta antibody [YE351]

Excellent
Abreviews
Abreviews
abreview image
Application
Western blot
Sample
Mouse Tissue lysate - whole (mouse brain)
Gel Running Conditions
Reduced Denaturing (4-20% gel)
Loading amount
20 µg
Specification
mouse brain
Blocking step
(agent) for 1 hour(s) and 0 minute(s) · Concentration: 100%
Read More
The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

Abcam user community

Verified customer

Submitted Apr 12 2021

Question

Hello,



I am looking for a PPP2CA (Uniprot P67775) specific antibody as opposed to PPP2CB (P62714).

Since the 2 proteins share 97.411% identity, I am not sure if any would be specific to one or the other.

Read More

Abcam community

Verified customer

Asked on Feb 08 2013

Answer

Thank you for your patience in awaiting our reply while we gathered our data on this. It does not appear that this has been specifically tested for our products but comparing the immunogens of our PP2CA antibodies there is a strong possibility that each will react in PP2CB as well. Please let me know if I can be of further assistance.

Read More

Abcam Scientific Support

Answered on Feb 08 2013

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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