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  1. Link

    products/primary-antibodies/ros1-antibody-4-6g-ab108492.pdf

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Signal Transduction Protein Phosphorylation Tyrosine Kinases Receptor Tyrosine Kinases
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Anti-ROS1 antibody [4-6G] (ab108492)

  • Datasheet
  • SDS
Reviews (3) Submit a question References (4)

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Find out more.

Key features and details

  • Mouse monoclonal [4-6G] to ROS1
  • Suitable for: IHC-Fr, IHC-P, IP, ICC/IF, Flow Cyt, WB
  • Reacts with: Human
  • Isotype: IgG1

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Overview

  • Product name

    Anti-ROS1 antibody [4-6G]
    See all ROS1 primary antibodies
  • Description

    Mouse monoclonal [4-6G] to ROS1
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Fr, IHC-P, IP, ICC/IF, Flow Cyt, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to ROS1. Extracellular portion of ROS amino acid 1-285 fused to Fc, transiently expressed in 293 cells and purified using PtnA column chromatography.

  • Positive control

    • Cells transiently expressing human ROS1, mouse cells expressing human ROS1.
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    Constituent: PBS
  • Concentration information loading...
  • Purity

    Protein A/G purified
  • Clonality

    Monoclonal
  • Clone number

    4-6G
  • Myeloma

    Sp2
  • Isotype

    IgG1
  • Research areas

    • Signal Transduction
    • Protein Phosphorylation
    • Tyrosine Kinases
    • Receptor Tyrosine Kinases
    • Epigenetics and Nuclear Signaling
    • Transcription
    • Cancer susceptibility
    • Proto-oncogenes
    • Cancer
    • Oncoproteins/suppressors
    • Oncoproteins
    • Growth factors

Associated products

  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Isotype control

    • Mouse IgG1, kappa monoclonal [15-6E10A7] - Isotype Control (ab170190)
  • Recombinant Protein

    • Recombinant human ROS1 (mutated G2032R) protein (ab206012)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab108492 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr (3)
Use at an assay dependent concentration.
IHC-P
Use at an assay dependent concentration.
IP
Use at an assay dependent concentration.
ICC/IF
Use at an assay dependent concentration.
Flow Cyt
Use at an assay dependent concentration.

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

WB
Use at an assay dependent concentration.
Notes
IHC-Fr
Use at an assay dependent concentration.
IHC-P
Use at an assay dependent concentration.
IP
Use at an assay dependent concentration.
ICC/IF
Use at an assay dependent concentration.
Flow Cyt
Use at an assay dependent concentration.

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

WB
Use at an assay dependent concentration.

Target

  • Function

    This is probably a cell growth or differentiation factor receptor with a tyrosine-protein kinase activity.
  • Tissue specificity

    Expressed in brain. Expression is increased in primary gliomas.
  • Involvement in disease

    Note=A chromosomal aberration involving ROS1 is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.
  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 9 fibronectin type-III domains.
    Contains 1 protein kinase domain.
  • Cellular localization

    Membrane.
  • Target information above from: UniProt accession P08922 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 6098 Human
    • Omim: 165020 Human
    • SwissProt: P08922 Human
    • Unigene: 1041 Human
    • Alternative names

      • c ros 1 antibody
      • c ros antibody
      • c ros oncogene 1 receptor tyrosine kinase antibody
      • c Ros receptor tyrosine kinase antibody
      • c ros1 antibody
      • MCF 3 antibody
      • MCF3 antibody
      • Oncogene ROS antibody
      • OTTHUMP00000017814 antibody
      • OTTHUMP00000017815 antibody
      • OTTHUMP00000040389 antibody
      • Proto oncogene c ros 1 protein antibody
      • Proto oncogene c Ros antibody
      • Proto oncogene tyrosine protein kinase ROS antibody
      • Proto oncogene tyrosine protein kinase ROS precursor antibody
      • Proto-oncogene c-Ros-1 antibody
      • Proto-oncogene tyrosine-protein kinase ROS antibody
      • Receptor tyrosine kinase c ros oncogene 1 antibody
      • Ros 1 antibody
      • ROS 1C antibody
      • ROS antibody
      • ROS proto oncogene 1 , receptor tyrosine kinase antibody
      • ROS_HUMAN antibody
      • ROS1 antibody
      • ROS1C antibody
      • Transmembrane tyrosine specific protein kinase antibody
      • v ros avian UR2 sarcoma virus oncogene homolog 1 antibody
      • v ros UR2 sarcoma virus oncogene homolog 1 antibody
      see all

    Protocols

    • Flow cytometry protocols
    • Immunoprecipitation protocols
    • Immunohistochemistry protocols
    • Immunocytochemistry & immunofluorescence protocols
    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (4)

    Publishing research using ab108492? Please let us know so that we can cite the reference in this datasheet.

    ab108492 has been referenced in 4 publications.

    • Zhang X  et al. The CtBP1-HDAC1/2-IRF1 transcriptional complex represses the expression of the long noncoding RNA GAS5 in human osteosarcoma cells. Int J Biol Sci 15:1460-1471 (2019). PubMed: 31337976
    • Fei J  et al. Low concentration of rutin treatment might alleviate the cardiotoxicity effect of pirarubicin on cardiomyocytes via activation of PI3K/AKT/mTOR signaling pathway. Biosci Rep 39:N/A (2019). PubMed: 31138757
    • Shih CH  et al. EZH2-mediated upregulation of ROS1 oncogene promotes oral cancer metastasis. Oncogene 36:6542-6554 (2017). PubMed: 28759046
    • Deng G  et al. Downregulation of ROS-FIG inhibits cell proliferation, colony-formation, cell cycle progression, migration and invasion, while inducing apoptosis in intrahepatic cholangiocarcinoma cells. Int J Mol Med 34:661-8 (2014). WB, IHC-P ; Human . PubMed: 24968753

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    1-3 of 3 Abreviews or Q&A

    Immunohistochemistry (Frozen sections) abreview for Anti-ROS antibody [4-6G]

    Good
    Abreviews
    Abreviews
    Application
    Immunohistochemistry (Frozen sections)
    Sample
    Human Tissue sections (Liver)
    Specification
    Liver
    Fixative
    Acetone
    Permeabilization
    No
    Blocking step
    Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 20°C
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    Submitted Jan 04 2013

    Immunohistochemistry (Frozen sections) abreview for Anti-ROS antibody [4-6G]

    Inconclusive
    Abreviews
    Abreviews
    Application
    Immunohistochemistry (Frozen sections)
    Sample
    Rat Tissue sections (Liver)
    Specification
    Liver
    Fixative
    Methanol
    Blocking step
    Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 23°C
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    Submitted Aug 06 2012

    Immunohistochemistry (Frozen sections) abreview for Anti-ROS antibody [4-6G]

    Good
    Abreviews
    Abreviews
    Application
    Immunohistochemistry (Frozen sections)
    Sample
    Human Tissue sections (Liver)
    Specification
    Liver
    Fixative
    Methanol
    Blocking step
    Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 23°C
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    Submitted Aug 03 2012

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