Anti-SCP1 antibody (ab15090)
Key features and details
- Rabbit polyclonal to SCP1
- Suitable for: IHC-Fr, IHC-P, ICC/IF
- Reacts with: Mouse
- Isotype: IgG
Overview
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Product name
Anti-SCP1 antibody
See all SCP1 primary antibodies -
Description
Rabbit polyclonal to SCP1 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Fr, IHC-P, ICC/IFmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
Synthetic peptide corresponding to Mouse SCP1 (C terminal).
Database link: Q62209 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: Tris citrate/phosphate -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab15090 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-Fr | (1) |
Use at an assay dependent concentration.
|
IHC-P | (1) |
1/750.
|
ICC/IF | (1) |
1/100 - 1/750.
|
Notes |
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IHC-Fr
Use at an assay dependent concentration. |
IHC-P
1/750. |
ICC/IF
1/100 - 1/750. |
Target
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Function
Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. -
Tissue specificity
Testis. -
Domain
Consists of an alpha-helical stretch of 700 AA residues, flanked by N- and C-terminal globular domains. The C-terminal domain has DNA-binding capacity. -
Cellular localization
Nucleus. Chromosome. In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Found only where the chromosome cores are synapsed. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex. - Information by UniProt
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Database links
- Entrez Gene: 20957 Mouse
- SwissProt: Q62209 Mouse
- Unigene: 243849 Mouse
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Alternative names
- Cancer/testis antigen 8 antibody
- CT8 antibody
- HOM TES 14 antibody
see all
Images
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SCP1 labeled in mouse pachytene preparation (red), using ab15090. CDK2 staining, near teleomeres, is also present (green).
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Paraffin embeded IHC image of Murine SCP1 in mouse ovary using ab15090 at 1:750 dilution and secondary at 1:400.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (102)
ab15090 has been referenced in 102 publications.
- Pereira C et al. Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis. Elife 11:N/A (2022). PubMed: 35133274
- Tanno N et al. FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis. iScience 25:104008 (2022). PubMed: 35310947
- Dang H et al. Centrosome linker protein C-Nap1 maintains stem cells in mouse testes. EMBO Rep 23:e53805 (2022). PubMed: 35599622
- Horisawa-Takada Y et al. Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis. Nat Commun 12:3184 (2021). PubMed: 34075040
- Fang K et al. Prediction and Validation of Mouse Meiosis-Essential Genes Based on Spermatogenesis Proteome Dynamics. Mol Cell Proteomics 20:100014 (2021). PubMed: 33257503