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RecombinantRabMAb

Recombinant Anti-SERPINE2/PN-1 antibody [EPR8776] (ab134905)

Submit a review Submit a question References (1)
Western blot - Anti-SERPINE2/PN-1 antibody [EPR8776] (ab134905)
  • OI-RD Scanning - Anti-SERPINE2/PN-1 antibody [EPR8776] (ab134905)
  • Anti-SERPINE2/PN-1 antibody [EPR8776] (ab134905)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR8776] to SERPINE2/PN-1
  • Suitable for: WB
  • Reacts with: Rat, Human

Conjugates logo Related conjugates and formulations

Carrier Free

Overview

  • Product name

    Anti-SERPINE2/PN-1 antibody [EPR8776]
    See all SERPINE2/PN-1 primary antibodies

  • Description

    Rabbit monoclonal [EPR8776] to SERPINE2/PN-1

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP

  • Species reactivity

    Reacts with: Rat, Human

  • Immunogen

    Synthetic peptide within Human SERPINE2/PN-1 aa 300-400. The exact sequence is proprietary.

  • Positive control

    • C6, Human fetal brain, and Human oligodendroglioma cell lysates.

  • General notes

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.

Properties

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab134905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
1/1000 - 1/10000. Predicted molecular weight: 44 kDa.
Notes
WB
1/1000 - 1/10000. Predicted molecular weight: 44 kDa.
Application notes
Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

Target

  • Function

    Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

  • Sequence similarities

    Belongs to the serpin family.

  • Cellular localization

    Secreted > extracellular space.
  • Information by UniProt

  • Database links

    • Alternative names

      • GDN antibody
      • GDN_HUMAN antibody
      • GDNPF antibody
      • Glia derived nexin antibody
      • Glia-derived nexin antibody
      • Glial derived neurite promoting factor antibody
      • P17 antibody
      • Peptidase inhibitor 7 antibody
      • Pi-7 antibody
      • Plasminogen activator inhibitor type 1, member 2 antibody
      • PN-1 antibody
      • PN1 antibody
      • PNI antibody
      • Protease inhibitor 7 antibody
      • Protease nexin 1 antibody
      • Protease nexin I antibody
      • Serpin E2 antibody
      • Serpin family E member 2 antibody
      • Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 antibody
      • SERPINE 2 antibody
      • Serpine2 antibody
      see all

    Images

    • Western blot - Anti-SERPINE2/PN-1 antibody [EPR8776] (ab134905)
      Western blot - Anti-SERPINE2/PN-1 antibody [EPR8776] (ab134905)
      All lanes : Anti-SERPINE2/PN-1 antibody [EPR8776] (ab134905) at 1/1000 dilution

      Lane 1 : C6 cell lysate
      Lane 2 : Human fetal brain tissue lysate
      Lane 3 : Human oligodendroglioma cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 44 kDa

    • OI-RD Scanning - Anti-SERPINE2/PN-1 antibody [EPR8776] (ab134905)
      OI-RD Scanning - Anti-SERPINE2/PN-1 antibody [EPR8776] (ab134905)
      Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD
    • Anti-SERPINE2/PN-1 antibody [EPR8776] (ab134905)
      Anti-SERPINE2/PN-1 antibody [EPR8776] (ab134905)

    References (1)

    Publishing research using ab134905? Please let us know so that we can cite the reference in this datasheet.

    ab134905 has been referenced in 1 publication.

    • Chen P  et al. Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. Cancer Cell 35:868-884.e6 (2019). PubMed: 31185211

    Customer reviews and Q&As

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