Recombinant Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (ab137083)
![Western blot - Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (ab137083)](https://www.abcam.com/ps/products/137/ab137083/Images/ab137083-151650-anti-somatostatin-receptor-1-antibody-umb7-western-blot.jpg "Western blot - Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (ab137083)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [UMB7] to Somatostatin Receptor 1/SSTR1
- Suitable for: WB, ICC/IF
- Reacts with: Human
Related conjugates and formulations
Overview
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Product name
Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7]
See all Somatostatin Receptor 1/SSTR1 primary antibodies -
Description
Rabbit monoclonal [UMB7] to Somatostatin Receptor 1/SSTR1 -
Host species
Rabbit -
Tested applications
Suitable for: WB, ICC/IFmore details
Unsuitable for: IHC-P or IP -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide within Human Somatostatin Receptor 1/SSTR1 aa 350-450. The exact sequence is proprietary.
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Positive control
- Human fetal lung and Human small intestine lysates; 2936E cells.
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General notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20ºC. -
Storage buffer
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 0.31% Sodium citrate, 0.175% Sodium chloride, 0.0172% EDTA, 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
UMB7 -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab137083 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB |
1/500. Predicted molecular weight: 43 kDa.
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| ICC/IF |
1/250 - 1/500.
|
| Notes |
|---|
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WB
1/500. Predicted molecular weight: 43 kDa. |
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ICC/IF
1/250 - 1/500. |
Target
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Function
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. -
Tissue specificity
Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 6751 Human
- Omim: 182451 Human
- SwissProt: P30872 Human
- Unigene: 248160 Human
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Alternative names
- G-protein coupled receptor antibody
- Somatostatin R1 antibody
- Somatostatin receptor 1 antibody
see all
Images
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Western blot - Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (ab137083)All lanes : Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (ab137083) at 1/500 dilution
Lane 1 : Human fetal lung lysates
Lane 2 : Human small intestine lysates
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : goat anti-rabbit HRP at 1/2000 dilution
Predicted band size: 43 kDa -
![Immunocytochemistry/ Immunofluorescence - Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (ab137083)](https://www.abcam.com/ps/products/137/ab137083/Images/ab137083-151649-anti-somatostatin-receptor-1-antibody-umb7-immunofluorescence.jpg)
Immunocytochemistry/ Immunofluorescence - Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (ab137083)Immunofluorescent analysis of 2936E cells labelling Somatostatin Receptor 1/SSTR1 with ab137083 at 1/250 dilution.
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![Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (ab137083)](https://www.abcam.com/ps/products/137/ab137083/Images/ab137083-3-benefits-of-recombinant-antibodies.png)
Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (ab137083)
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (12)
ab137083 has been referenced in 12 publications.
- Flores-Martinez Á et al. Quantitative Analysis of Somatostatin and Dopamine Receptors Gene Expression Levels in Non-functioning Pituitary Tumors and Association with Clinical and Molecular Aggressiveness Features. J Clin Med 9:N/A (2020). PubMed: 32971845
- Ehrstedt C et al. Somatostatin receptor expression and mTOR pathway activation in glioneuronal tumours of childhood. Seizure 76:123-130 (2020). PubMed: 32062323
- Vesterinen T et al. Somatostatin Receptor Expression Is Associated With Metastasis and Patient Outcome in Pulmonary Carcinoid Tumors. J Clin Endocrinol Metab 104:2083-2093 (2019). PubMed: 30657933
- Zou Y et al. Expression and selective activation of somatostatin receptor subtypes induces cell cycle arrest in cancer cells. Oncol Lett 17:1723-1731 (2019). PubMed: 30675231
- Storvall S et al. Somatostatin receptor expression in parathyroid neoplasms. Endocr Connect 8:1213-1223 (2019). PubMed: 31336364