Anti-TELO2 antibody (ab122722)
Key features and details
- Rabbit polyclonal to TELO2
- Suitable for: IHC-P, WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-TELO2 antibody -
Description
Rabbit polyclonal to TELO2 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WB, ICC/IFmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant Protein Epitope Signature Tag antigen, corresponding to amino acids 361 - 462 of Human TELO2 (Q9Y4R8).
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Positive control
- Human urinary bladder tissue
RT-4, U-251 MG and Human tonsil lysate
Human cell line U-251 MG
- Human urinary bladder tissue
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine) -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab122722 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P |
1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| WB |
Use a concentration of 0.04 - 0.4 µg/ml.
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| ICC/IF |
Use a concentration of 0.25 - 2 µg/ml.
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| Notes |
|---|
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IHC-P
1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
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WB
Use a concentration of 0.04 - 0.4 µg/ml. |
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ICC/IF
Use a concentration of 0.25 - 2 µg/ml. |
Target
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Function
May be involved in telomere length regulation. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. -
Sequence similarities
Belongs to the TEL2 family. -
Cellular localization
Cytoplasm. Membrane. Nucleus. Chromosome > telomere. - Information by UniProt
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Database links
- Entrez Gene: 9894 Human
- Omim: 611140 Human
- SwissProt: Q9Y4R8 Human
- Unigene: 271044 Human
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Alternative names
- CLK2 antibody
- hCLK2 antibody
- KIAA0683 antibody
see all
Images
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Western blot - Anti-TELO2 antibody (ab122722)All lanes : Anti-TELO2 antibody (ab122722) at 1/250 dilution
Lane 1 : RT-4
Lane 2 : U-251 MG
Lane 3 : Human plasma
Lane 4 : Human liver lysate
Lane 5 : Human tonsil lysate -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TELO2 antibody (ab122722)ab122722, at 1/50 dilution, staining TELO2 in paraffin-embedded Human urinary bladder tissue by Immunohistochemistry. -
Immunocytochemistry/ Immunofluorescence - Anti-TELO2 antibody (ab122722)ab122722, at 4 ug/ml, staining TELO2 in Human cell line U-251 MG by Immunoflourosence.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab122722 has been referenced in 3 publications.
- Guo Z et al. TELO2 induced progression of colorectal cancer by binding with RICTOR through mTORC2. Oncol Rep 45:523-534 (2021). PubMed: 33416177
- Conde-Rubio MDC et al. The proteolytic landscape of cells exposed to non-lethal stresses is shaped by executioner caspases. Cell Death Discov 7:164 (2021). PubMed: 34226511
- Feng SW et al. Overexpression of TELO2 decreases survival in human high-grade gliomas. Oncotarget 7:46056-46066 (2016). WB, IHC . PubMed: 27329594