Anti-Thyroglobulin antibody [5F9] (ab1984)
Key features and details
- Mouse monoclonal [5F9] to Thyroglobulin
- Suitable for: Sandwich ELISA, EIA
- Reacts with: Cow, Human
- Isotype: IgG2a
Overview
-
Product name
Anti-Thyroglobulin antibody [5F9]
See all Thyroglobulin primary antibodies -
Description
Mouse monoclonal [5F9] to Thyroglobulin -
Host species
Mouse -
Specificity
This antibody does not interfere with anti-thyroglobulin autoantibodies. -
Tested applications
Suitable for: Sandwich ELISA, EIAmore details -
Species reactivity
Reacts with: Cow, Human -
Immunogen
Full length native protein (purified) corresponding to Thyroglobulin.
-
General notes
Concentration varies from lot to lot and can be provided on request.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.1% Sodium azide -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
5F9 -
Myeloma
Sp2/0 -
Isotype
IgG2a -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab1984 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Sandwich ELISA |
Use at an assay dependent concentration.
|
|
| EIA |
Use at an assay dependent concentration.
|
| Notes |
|---|
|
Sandwich ELISA
Use at an assay dependent concentration. |
|
EIA
Use at an assay dependent concentration. |
Target
-
Function
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). -
Tissue specificity
Thyroid gland specific. -
Involvement in disease
Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. -
Sequence similarities
Belongs to the type-B carboxylesterase/lipase family.
Contains 11 thyroglobulin type-1 domains. -
Post-translational
modificationsSulfated tyrosines are desulfated during iodination. -
Cellular localization
Secreted. - Information by UniProt
-
Database links
- Entrez Gene: 280706 Cow
- Entrez Gene: 7038 Human
- Omim: 188450 Human
- SwissProt: P01267 Cow
- SwissProt: P01266 Human
- Unigene: 654591 Human
-
Alternative names
- AITD 3 antibody
- AITD3 antibody
- hTG antibody
see all
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab1984 has not yet been referenced specifically in any publications.